Diaskintest is it possible to drink alcohol?

Compatibility of Diaskintest and alcohol

? To check compatibility with a particular substance, special tests are carried out. During studies of the effect of alcohol and its derivatives on this medicine, doctors were unable to identify obvious contraindications.

A side effect of the drug is considered to be a toxic effect on the liver, kidneys and urinary system, so you should still avoid drinking alcohol.

The medication has passed all the necessary medical tests and is officially considered a safe medicine that has no contraindications regarding compatibility with alcohol.

People with intolerance to the components of the drug are better off avoiding alcoholic beverages to minimize the risk of complications.

Antihistamines: myths and truth

Natalya Stefanova , doctor of the highest category, candidate of medical sciences, allergist-immunologist (City Clinical Hospital No. 31, Moscow) New Pharmacy , October 2011, pp. 96–97

Today, every third person suffers from one or another allergic pathology and the number of allergy sufferers is growing rapidly from year to year. Antihistamines are one of the most commonly used groups of drugs for the treatment of allergies. They have been known since the 40s of the last century, and during this more than half a century of history of their use, many myths have accumulated, both among consumers of this group of products and among specialists: doctors and pharmacists.

We talked about this with Natalya Igorevna Stefanova, a doctor of the highest category, candidate of medical sciences, allergist-immunologist (City Clinical Hospital No. 31, Moscow).

As is known, histamine, the most important mediator of inflammation, is responsible for the occurrence of an allergic reaction in the body, under the influence of which a number of physiological and pathological processes occur. Numerous studies have shown that this substance, by acting on receptors in the respiratory system, eyes and skin, causes characteristic allergy symptoms.

Histamine was chemically synthesized in 1907, and later scientists were able to isolate it from animal and human tissues. And already in 1936, substances were created that could block the action of histamine in the body. On their basis, the first antihistamines arose. This term refers to drugs that selectively block the effect of histamine on H1 receptors and are used to treat allergic diseases.

All antihistamines have common features. For example, each drug in this group has the following effects: antipruritic, decongestant, antiexudative, but the mechanisms of action and the range of side effects for these drugs are different.

Myth #1: Antihistamines can cure allergies.

Unfortunately, these drugs cannot cure allergies, they only help control the disease. The mechanism of their action is as follows: by blocking H1 receptors, drugs of this group do not allow the inflammatory mediator - histamine - to connect with cells. At the same time, stimulation of nerve endings and the release of allergy mediators from cells stops, swelling, inflammatory reaction and itching decrease.

Myth No. 2: the most effective and safest are third-generation antihistamines.

Many people believe that there are three generations of antihistamines. This is absolutely contrary to the generally accepted classification. According to the Antihistamine Consensus, there are only two generations of antihistamines.

First generation drugs cause drowsiness, depress the central nervous system and reduce concentration. Therefore, most of these medications should not be used when performing work that requires attention.

Second-generation drugs practically do not penetrate the blood-brain barrier, and therefore do not reduce the patient’s mental and physical activity. In addition, the first and second generations of antihistamines differ from each other in the presence or absence of side effects associated with stimulation of other types of receptors, duration of action, and development of addiction.

Myth No. 3: First-generation antihistamines have the largest evidence base and are also very good for insomnia.

Misconception again. First-generation drugs were registered long before regulatory authorities began to require evidence of their effectiveness and safety, so a priori representatives of the second generation of antihistamines have more of these studies.

In addition, outdated first-generation drugs have a wide range of side effects, which is why their sales are limited in many developed countries.

Even in case of insomnia, it is better not to use first-generation antihistamines. The fact is that the sleep they induce is not physiological. These drugs inhibit the REM phase of sleep, with a pronounced withdrawal syndrome, so when you wake up, a person feels exhausted and not rested. They can also depress breathing and increase the risk of sleep apnea.

Myth #4: There are antihistamines that do not cause drowsiness 100% of the time.

Alas, this is also not true. For first-generation drugs, sedation is a common occurrence. For second-generation drugs, there is rather an exception, a rare individual reaction, which, unfortunately, still occurs, although in very rare cases in particularly sensitive individuals, so in the instructions for any AGP you can find a sedative effect in the side effects.

Myth #5: Antihistamines have the same speed and duration of action.

Fundamentally wrong. “Classic” allergy medications begin to act quickly, but their therapeutic effect does not last long. A drug such as Cetrin® begins to act within 20 minutes after administration and remains effective throughout the whole day, so it can be taken only once a day. In addition, addiction does not develop to second-generation drugs, so there is no need to stop taking the course after 7-10 days, as is done when treating with old drugs.

Myth No. 6: All second-generation drugs are almost identical to each other.

This is not true. Before taking a second-generation antihistamine, you should carefully read its contraindications. Some of them cause cardiotoxicity, that is, they have a bad effect on the heart. Therefore, they should not be taken by patients with cardiovascular disorders and the elderly.

A number of drugs that undergo hepatic metabolism cannot be used in cases of liver dysfunction, and also cannot be combined with macrolide antibiotics, antifungal drugs, or washed down with grapefruit juice.

Drugs that are not metabolized in the liver are safer. One of them is Cetrin®. It will not cause harm, even if combined with other drugs, taken for liver diseases, prostate adenoma, gastric ulcer, bronchial asthma, glaucoma.

In addition to safety, this drug is highly effective. It not only selectively blocks histamine H1 receptors, but also has an anti-inflammatory effect. Thanks to this, Cetrin® is effective in the treatment of seasonal and year-round allergic rhinitis, conjunctivitis, allergic dermatoses, recurrent urticaria, and angioedema.

Myth #7: With the advent of safer second-generation drugs, there is no room for older antihistamines.

And that's not true. Only first-generation antihistamines are available in injection form, so they are indispensable in emergency care. Some of them (chloropyramine, dimethindene) are registered for children from 1 month, and 2nd generation drugs are registered only from 6 months (cetirizine). In addition, they are effective in the treatment of many pathologies not related to allergies (migraine, anxiety, motion sickness, etc.), which expands the scope of their application.

Myth No. 8: New drugs are much more expensive than first-generation drugs.

This is not true. You should always evaluate not the cost of 1 package, but the cost of 1 day of treatment or course of treatment. For example, Cetrin®, in terms of a course of treatment, will be more economical than many first-generation antihistamines.

Brief characteristics of the drug

The drug was created for early detection of signs of tuberculosis development. The main problem with the mantoux test was that the test could not completely distinguish a patient from someone who had already suffered tuberculosis.

The test is prescribed only on the recommendation of a TB doctor. Its effect is similar to the mantoux test and is carried out by intradermal injection of 0.1 ml.

Such diagnostics can distinguish a person with tuberculosis from one who has been vaccinated.

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Skin testing.

It is the most widely used and most useful tool for finding causative allergens.

There are several ways to perform skin testing, but they all involve applying a small amount of allergen to the skin and observing the reaction over a period of time (usually no more than 15 minutes). This means that the results of skin testing will be known almost immediately at the time of contacting an allergist.

The most modern method of skin testing is prick testing, which allows you to identify potentially significant allergens with minimal trauma to the skin (this is not “incisions” or even “scratching” of the skin, but barely perceptible pressure on the skin using a special tool - a pincer).

contraindications for this diagnostic method , and all of them must be taken into account by the allergist.

There is no age limit for skin testing. Don't believe in the myths that you have to wait until your child is 3 or 5 years old. A competent allergist will be able to conduct skin prick testing much earlier.

Although skin testing involves applying potentially significant allergens to the skin, it is relatively safe in the hands of a professional. In addition, medical institutions that diagnose allergies always have special equipment, skills and knowledge (!!!) to provide medical care if necessary.

Another way to diagnose allergies is

Use for alcoholism

The drug can be used in the presence of chronic alcoholism. But, due to the fact that ethanol breakdown products interact with the main components of the medication, the test must be carried out 24-30 hours after the last drink.

The drug does not contain tuberculosis pathogens, so it is not dangerous for children or people with low immunity and increased sensitivity to vaccines.

Studies have shown that the medication can be freely used by people suffering from alcoholism if they have not consumed alcoholic beverages.

Use for hangover

If you use the drug for a hangover, it is important to remember:

1. It is sensitive to acetaldehyde, a breakdown product of alcohol.
2. It is not recommended to use if you are feeling unwell or ill.

For a hangover, it is recommended to take the medicine 14 hours after drinking. Also, in case of a hangover, doctors advise taking sorbents along with special diuretics to get rid of unpleasant symptoms.

Testing for the presence of TB pathogens during a hangover may be less accurate.

Consequences of drinking alcohol

If you take Diaskintest with products containing alcohol, the medicine may give incorrect results. That is why it is recommended to avoid using the medicine with alcoholic beverages.

Doctors strongly do not recommend doing a test if there is alcohol in the blood, since with a false interpretation, the doctor may prescribe special preventive anti-tuberculosis therapy to an uninfected patient or underestimate the positive reaction of the drug and leave the person without the necessary treatment.

Also, in case of increased sensitivity of the patient to alcohol, use after a short period of time can lead to a number of unpleasant consequences:

1. Increased blood pressure, which increases the risk of nosebleeds.
2. Nausea, vomiting.

The test should not be administered to people with cardiovascular disease or diabetes, as this may cause an increase or decrease in blood glucose levels.

Indications for T-SPOT

• skin diseases (eg eczema) and autoimmune diseases;
• allergic reactions;
• epilepsy;
• dialysis;
• organ transplantation;
• convulsive syndrome;
• any chronic diseases in the acute stage (especially diabetes mellitus, pneumoconiosis);
• oncological diseases during therapy that suppresses the immune system (glucosteroid or radiation), as well as treatment with replacement of renal function;
• if extrapulmonary forms of tuberculosis are suspected;
• HIV infection.

T-SPOT can also be used to diagnose pregnant women if they have had contact with a patient with tuberculosis.

The T-SPOT test is complementary in immunodiagnosis, but can be used as a replacement for the Mantoux test or Diaskintest.

When can you do a test, after how long?

It is recommended to use the medicine after the alcohol has been completely processed in the body, that is, with a body weight of 60 kg, it takes about 6 hours for 100 grams of vodka to be eliminated from the body.

To quickly remove alcohol from the body, you can resort to the following actions:

1. Drinking plenty of fluids, which speeds up metabolism and removes all waste products from the body.
2. Drink strong tea with sugar.
3. Brew herbal teas as a drink.
4. Consume large amounts of sugar in the form of fruit or large amounts of protein from meat or fish products.
5. Engage in simple sports or mental exercises.

So, if you conduct a test before alcohol is removed from a person’s internal organs, there is a risk of complications; the general recommended period is 24 hours after consumption.

Only after a doctor’s prescription and recommendation should you start taking a test for tuberculosis.

How does T-SPOT differ from the Mantoux test and Dianskintest?

The most important difference is in the test procedure. In traditional methods of diagnosing tuberculosis disease - the Mantoux test and Diaskintest - intradermal administration of the drug is used. For the Mantoux test, purified tuberculin is used; for Diaskintest, these are proteins from tuberculosis bacteria. When substances get under the skin, a local reaction occurs, which is used to assess the presence of Mycobacterium tuberculosis in the body.

To diagnose a tuberculosis infection using a spot test, the patient’s blood is required, which will later be sent for testing to a laboratory. This is the main difference between the test and the Mantoux test and Diaskintest. Another similar test that is carried out in vitro is the quantiferon test. The main difference between the tests is in the research methodology. So, for example, the quantiferon test determines interferon gamma (it is produced in response to the introduction of the tuberculosis bacillus), and the spot test determines T cells (they produce interferon gamma in the presence of Mycobacterium tuberculosis).

When can you take the drug if you have been drinking alcohol?

If you first consumed alcohol, you need to wait 16 hours before testing. The test for tuberculosis must be done in full accordance with the recommendations of doctors.

You also need to take into account that you will need an examination and consultation with a doctor who, based on the characteristics of the body, can tell you exactly how to do a test for tuberculosis.

The alcohol breakdown product will negatively affect the tuberculosis test, which may result in incorrect results. Alcoholism has no effect on the quality of the test, and also does not cause unpleasant consequences for the body.

Any drug has a negative effect on a person, so ideally it is better to abstain from alcohol so as not to aggravate the patient’s condition.

Contraindications

Only a doctor can decide whether Diaskintest is suitable for testing for tuberculosis.

The Diaskintest test is not recommended and is not performed on children under 7 years of age inclusive.

"Diaskintest" is contraindicated for persons with allergic and autoimmune diseases! Also, the use of Diaskintest is contraindicated in the following cases:

• Acute diseases or exacerbation of chronic diseases (except for cases of suspected tuberculosis).
• Skin diseases.
• Epilepsy.
• In children's groups where there is a quarantine for childhood infections, the test is carried out only after the quarantine is lifted.

Diaskintest and beer

Diaskintest and beer are incompatible. If a person has been tested, it is better not to drink alcoholic beverages.

When taken in large quantities, the immune function is suppressed and health worsens. Therefore, the sample may be unreliable. But the reaction is typical for patients who abuse beer and other alcohol.

A repeat test will be required, which can only be done 6 months after the previous test. During this time, the bacteria will spread throughout the body, causing damage to the lungs, kidneys and other organs.

If a person drinks a small amount of the drink, no negative effect will occur.

Organs affected by the toxin

The combined use of pharmacological agents and alcohol has a toxic effect on the internal organs and environments of the body. Alcohol, entering into a chemical reaction with a medicine, leads to poisoning, disrupts physiological processes, enhances or weakens the healing properties of drugs.

The liver suffers more than other organs. She gets hit twice. Many medications have a side effect - hepatotoxicity, destroy cells, and disrupt the physiology of the organ. In the liver, alcohol breaks down to ethanal, a substance 20-30 times more toxic than ethanol, which causes the death of hepatocytes.

Dangerous groups of drugs for the organ in combination with alcohol:

• anti-inflammatory;
• hormonal;
• antibacterial;
• antifungal;
• glucose control agents for diabetes mellitus;
• anti-tuberculosis;
• cytostatics (chemotherapy drugs);
• tranquilizers (anti-epileptic, psychotropic).

In second place among the internal organs exposed to the harmful effects of alcohol together with medications are the heart and vascular system. Strong drinks during drug therapy constrict blood vessels and increase blood pressure. The simultaneous intake of alcohol and chemical substances leads to failure of the myocardium and increases the risk of developing an attack of angina pectoris and a heart attack.

A mixture of ethanol and pharmaceuticals disrupts the quality of the blood and reduces clotting. This is dangerous due to internal bleeding and strokes.

Indications for use of "Diaskintest"

"Diaskintest" is used to conduct an intradermal test in children over 8 years of age, instead of the Mantoux test, for the purpose of diagnosing tuberculosis of exclusively pulmonary localization, assessing the activity of the process and identifying patients at high risk of developing an active tuberculosis process. "Diaskintest" is intended for performing an intradermal test for the following purposes:

• children from high-risk groups for tuberculosis who are not subject to dispensary registration by a phthisiatrician
• to identify patients at high risk of developing active tuberculosis (latent tuberculosis infection)
• for differential diagnosis of post-vaccination (BCG) and infectious allergies (delayed-type hypersensitivity)
• to evaluate the effectiveness of anti-tuberculosis treatment in combination with other methods
• in patients suffering from diabetes mellitus, peptic ulcer disease
• in patients with chronic nonspecific purulent-inflammatory diseases of the bronchopulmonary system and kidneys
• in HIV-infected patients
• in patients receiving long-term immunosuppressive therapy (cytostatics, corticosteroids, genetically engineered biological drugs (GEBP), etc.)

Rules for taking medications and alcohol

Drinking alcohol during treatment minimizes the clinical effect of therapy and creates a risk of developing complications of the disease.

If this cannot be avoided, follow the rules of behavior that will reduce the occurrence of negative consequences:

1. Do not drink strong drinks (vodka, cognac, whiskey), choose dry wine (100-150 ml), beer (no more than 300 ml). Don't drink alcohol on an empty stomach.
2. The interval between taking the medicine and alcohol should be at least 2 hours.
3. To reduce the toxic effect, take medications that protect the liver (hepatoprotectors), pancreas (pancreatin), and stomach (antacids ─ Rennie, Almagel).

If a person takes antiviral medications for colds, anti-inflammatory drugs, alcohol in moderation does not pose a threat to the body.

Alcoholic drinks during treatment are strictly contraindicated in cases of liver cirrhosis, severe infectious diseases, and during a course of chemotherapy.

Medicines, alcohol and chronic diseases

If a person has chronic diseases, simultaneous use of alcohol and medications is potentially dangerous for the functioning of vital organs. Since patients systematically take prescribed medications, the influence of alcohol can lead to negative consequences.

People with chronic heart disease (angina pectoris, heart defects) develop arrhythmias of varying severity. Heart attacks with severe pain syndrome develop, which is not relieved by Nitroglycerin, and the risk of developing myocardial infarction increases significantly.

In case of chronic liver diseases (viral hepatitis, hepatosis), alcohol during treatment can become a trigger in the development of cirrhosis and hepatocellular carcinoma (cancer).

Drinking alcohol during cirrhosis leads to the following consequences:

• bleeding into the abdominal cavity;
• liver decomposition, infection, peritonitis;
• hepatic coma;
• death.

If a person is on long-term treatment with sedatives, psychotropic drugs, tranquilizers, he is contraindicated in drinking alcohol. This leads to severe depression and the appearance of obsessive states (hallucinations, phobias). Suicidal feelings develop. Such a patient needs constant monitoring and assistance from a psychiatrist.

The principle of action of the drug "Diaskintest"

The action of the drug "Diaskintest" is based on the detection of a cellular immune response to antigens specific to Mycobacterium tuberculosis. When the drug is administered intradermally in persons with tuberculosis infection, a specific skin reaction occurs, which is a manifestation of delayed-type hypersensitivity.

To identify (diagnosis) tuberculosis infection, a test with Diaskintest is carried out:

• children sent to an anti-tuberculosis institution for additional examination for the presence of a tuberculosis process;
• children belonging to high-risk groups for tuberculosis, taking into account epidemiological, medical and social risk factors;
• children referred to a phthisiatrician based on the results of mass tuberculin diagnostics (Mantoux).

Important! A test with the drug "Diaskintest" cannot be used instead of a tuberculin test (Mantoux) to select individuals for primary vaccination and revaccination with BCG

The most dangerous combinations and consequences

The combination of alcohol and chemical-based drugs can lead to serious disorders in the body, and in some cases to fatal consequences.

List of medications and their side effects in combination with alcohol: