Manufacturer: GlaxoSmithKline, Belgium.
Unfortunately, the Priorix vaccine is no longer imported into the Russian Federation, but instead a similar vaccine M-M-P II produced in Holland has appeared, read more about this vaccine HERE.
The vaccine is certified and of adequate quality. Vaccination is carried out in compliance with all requirements. The results of a general blood and urine test are first required; the child will be examined by a pediatrician immediately before vaccination. All information is entered into the child’s medical record, and a certificate of vaccination is issued.
Description of the drug
The Priorix vaccine is a combination attenuated vaccine designed to prevent measles, rubella and mumps.
The Priorix vaccine contains attenuated (weakened) vaccine strains of the measles virus (Schwarz), mumps (RIT 4385, derivative of Jeryl Lynn) and rubella (Wistar RA 27/3), which are cultivated separately in chicken embryo cell culture (measles and mumps viruses) and human diploid cells (rubella virus), which allows you to simultaneously (with one injection) immunize a child against three infectious diseases: measles, rubella and mumps.
Measles is a highly contagious viral infection transmitted by airborne droplets. The measles virus mainly affects the upper respiratory tract and lungs, which is manifested by acute laryngitis with necrosis of the laryngeal mucosa, prolonged bronchitis and severe pneumonia. For 6-12 months after the illness, the body is in a state of severe immunodeficiency, which is manifested by frequent and severe respiratory diseases.
Rubella is a highly contagious viral infection transmitted by airborne droplets. Rubella can be congenital or acquired.
Acquired rubella is manifested by a widespread small-spotted rash, swollen lymph nodes and severe intoxication.
Congenital rubella is a chronic intrauterine infection of the fetus. The virus is transmitted from mother to child through the placental barrier, leading to fetal death, early miscarriage or severe developmental defects and deformities, such as deafness, cataracts, various heart and brain defects, often incompatible with life.
Mumps is a highly contagious viral infection transmitted by airborne droplets. Mumps is manifested by severe intoxication, damage to the salivary glands, the central nervous system (including meningitis), pancreatitis, orchitis (inflammation of the testicles, often leading to infertility).
Priorix® (Vaccine against measles, mumps and rubella, live culture) (Priorix®)
Method of administration
Priorix® is administered subcutaneously; intramuscular administration of the drug into the deltoid region of the shoulder or the anterior outer surface of the thigh is allowed.
In persons with bleeding disorders (eg, thrombocytopenia or coagulation disorders), the vaccine should be administered subcutaneously.
Priorix® cannot be administered intravascularly
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Before use, the solvent and the reconstituted drug must be visually checked for the absence of mechanical inclusions and/or changes in appearance (see section “Description”). If they are detected, you should stop using the solvent or reconstituted drug.
Priorix® vaccine cannot be mixed in the same syringe with other vaccines. Immediately before use, add the contents of the supplied syringe or ampoule with solvent into the bottle with the drug at the rate of 0.5 ml per 1 dose. A new sterile needle must be used to administer the drug.
Preparation of the vaccine before administration using a solvent in an ampoule
Priorix® vaccine must be reconstituted by adding the full volume of diluent from the ampoule to the vial containing the lyophilisate. After adding the solvent to the lyophilisate, shake the resulting mixture well until the lyophilisate is completely dissolved in the solvent (no more than 1 minute). After recovery, the vaccine must be administered immediately. A new needle should be used to administer the vaccine. For administration, all its contents are removed from the vial with the reconstituted vaccine.
Preparing the vaccine before administration using a solvent in a syringe
Priorix® vaccine must be reconstituted by adding the full volume of diluent from the prefilled syringe to the vial containing the lyophilisate.
Attention
! The packaging of the Priorix® vaccine can be presented in two types of syringes, differing in the way the needle is connected to the syringe nozzle.
To correctly select the method of connecting the needle and syringe, follow the instructions below:
Syringe type 1
Instructions for preparing a type 1 syringe (Figure 1) for use:
1. Unscrew the protective cap of the syringe by turning it counterclockwise (while holding the syringe by the barrel, avoiding contact with the syringe plunger).
2. Using a clockwise twisting motion, connect the needle to the syringe until you feel them snap together (see Figure 1).
3. Remove the protective cap from the needle (in some cases it may be tightly attached to the needle).
Syringe type 2
If the package contains a syringe other than the one shown in Figure 1, then after removing the protective cap from the syringe nozzle, insert the needle onto the syringe until it stops without additional twisting. Add the solvent to the lyophilisate. After adding the solvent to the lyophilisate, shake the resulting mixture well until the lyophilisate is completely dissolved in the solvent (no more than 1 minute). After recovery, the vaccine must be administered immediately. A new needle should be used to administer the vaccine. For administration, all its contents are removed from the vial with the reconstituted vaccine. The reconstituted vaccine is used immediately and cannot be stored. Unused drug and waste from its use must be destroyed in accordance with the requirements adopted in the Russian Federation.
Vaccination schedules
The vaccination dose of the vaccine is 0.5 ml.
In accordance with the Russian Preventive Vaccination Calendar, Priorix® is administered to children at the age of 12 months, followed by revaccination at the age of 6 years.
Priorix® can be administered to girls aged 13 years who have not previously been vaccinated or have received only one vaccination with monovalent or combined measles, rubella and mumps vaccines.
Side effects
Reactions to the Priorix vaccine are rare and most often do not require specific therapy.
Possible local reactions to vaccination: in the first 48 hours after administration of the vaccine, slight hyperemia (redness), swelling and pain at the injection site are possible. From the 5th to the 15th day the following may appear: a small-spotted rash, swelling of the lymph nodes.
However, we must remember that the infectious disease itself poses a greater danger to the child!
If you have any questions, you can always consult our pediatricians and vaccinologists. We always try to help you! Contact us!
Three diseases - one vaccine
Rubella is a viral infection.
You can become infected by airborne droplets, which makes the pathogen highly contagious (infectious). The disease is divided into two fundamentally different groups: congenital rubella and acquired. The first is, as the name implies, a chronic infection that can lead to fetal death in the early stages of pregnancy or to the appearance of serious anomalies during embryonic development. Congenital rubella begins when the virus infects a pregnant woman whose body does not have a protective antibody titer. Known ways to “earn” rubella immunity before pregnancy are through vaccination or a previous illness. However, there are a number of difficulties in this seemingly simple situation. Quite a lot of women refuse vaccination, being confident that they have immunity. Many of them are simply unaware and therefore underestimate the risk of infection. It is important to know that diagnosing rubella is quite difficult, and the diagnosis can often be erroneous. You can find out for sure about the presence of rubella immunity only by performing a blood test for specific antibodies to the rubella virus. Such an analysis can also be done in the CELT laboratory. Flu vaccination (Vaxigrip)
- Duration: 30 – 40 minutes
More details
Acquired rubella is an infection that is acquired throughout life and is manifested by typical symptoms: rash, intoxication. Both a child and an adult (who has not been sick before) can get sick. At the same time, adults tolerate rubella worse than children. This infection has a high risk of complications. The only reliable way to protect against congenital and acquired forms is vaccination, which can be given to both children and adults.
Another disease that the Priorix vaccine will protect against is measles. The disease is a viral infection, highly contagious, and transmitted by airborne droplets. The virus affects the mucous membrane of the respiratory tract, eyes, lymphatic and circulatory systems. The infectious process is manifested by high fever, inflammation of the upper and middle respiratory tract (runny nose, cough, hoarseness, croup), inflammation of the membranes of the eye (keratitis, conjunctivitis), lymph nodes (lymphadenitis), skin rash and often leads to complications (otitis, pneumonia, meningitis , encephalitis). Even with a successful recovery within a year, the body is in a state of anergy, that is, a decrease in immune defense, which in turn can lead to the development of bacterial complications.
Mumps (or simply “mumps”) is another viral infection that is highly contagious and dangerous to health. The disease occurs with damage to the salivary glands, pancreas, testicles, ovaries, mammary glands, nervous system, causes severe intoxication, and often causes infertility.
At CELT you can consult a pediatrician.
- Medical examination before preventive vaccination - 1,200
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How is vaccination carried out?
Vaccination is carried out in a vaccination room, in compliance with all sanitary requirements. All drugs are certified. A certificate for the drug is provided upon request.
Without reminders, before vaccination, the medical worker must show the drug and the expiration date of the vaccine.
Only sterile and disposable instruments are used. The vaccination must be carried out using disposable medical gloves.
On the day of vaccination, the child is examined by a pediatrician and the temperature is measured. In the absence of contraindications, vaccination is carried out. Information about the vaccination performed is entered into the card, vaccination certificate, and detailed recommendations for caring for the child in the post-vaccination period are given.
Before vaccination, the doctor will answer all your questions. Be sure to bring information about previous vaccinations to your appointment!
Please note that vaccination of a child, Mantoux test, Diaskintest can only be carried out in the presence of parents or legal representatives of the child (guardians), or if the accompanying person has a NOTARIZED power of attorney to carry out the manipulation (indicating the drug planned for administration) . Otherwise, vaccination will be denied. We comply with the laws of the Russian Federation.
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Vaccine composition and application features
The composition of the vaccine is weakened mumps viruses (Jeryl Lynn-strain), measles (Schwarz-strain) and rubella (Wistar RA 27/3-strain). This combination allows you to immunize the patient against three diseases at once, using only one injection.
Indications
- Planned prevention of any of the three diseases for adults and children over one year of age.
- Emergency prevention. It is used after an unvaccinated patient has come into contact with the measles virus for 3 days. Allows you to alleviate the duration, symptoms and course of the disease.
The effectiveness of the Priorix vaccine
When a vaccine is administered, the human body produces antibodies in response to foreign agents. Numerous clinical trials were conducted with the Priorix vaccine on a large statistical sample, which showed the high effectiveness of the drug. After vaccination, protective bodies against measles were found in 98% of those vaccinated, against mumps - in 96%, and against rubella - in 99%. A repeated test for antibodies to viruses a year later revealed active antibodies against measles and rubella in the same number of vaccinated people, and against mumps in 88% of those examined.
The Priorix vaccine has been approved by international organizations (such as WHO) and meets all safety and effectiveness requirements.
