Lincomycin for children for the treatment of infections of the ENT organs, stomatitis

pharmachologic effect

An antimicrobial agent that belongs to the group of lincosamides. Its bacteriostatic effect is noted in relation to a wide range of microorganisms. If higher doses of the drug are used, it may produce a bactericidal effect.

The mechanism of the antimicrobial effect of the antibiotic is as follows: under its influence, protein synthesis is inhibited in the cells of microorganisms. It has pronounced activity against gram-positive anaerobic and aerobic microorganisms. Resistance to the influence of the drug is demonstrated by strains of Enterococcus faecalis, as well as viruses, fungi, and protozoa. Most gram-negative microorganisms are also resistant to it. Slow development of resistance to this drug has been noted. Cross-resistance of this substance with clindamycin has been noted.

What is Lincomycin

So, here is a popular medicine, which in Latin recipes is called Lyncomycini hydrochloridi. Like any antimicrobial drug, it has its own characteristics of use and interactions with other drugs.

There are people with intolerance and various diseases for which this drug is contraindicated.

The antimicrobial drug Lincomycin is a broad-spectrum antibiotic, providing an active bacteriostatic/bactericidal effect against staphylococci, streptococci, mycoplasma, and other pathogenic microorganisms. How it works? The mechanism is simple. The substance interferes with the process of protein production inside bacterial cells.

Pharmacokinetics and pharmacodynamics

After oral administration, lincomycin hydrochloride is rapidly absorbed from the gastrointestinal tract. About 50% of the substance enters the systemic circulation. It is 75% bound to plasma proteins, the highest concentration is observed 2-4 hours after oral administration. The substance penetrates into fluids and organ tissues. The highest concentrations are observed in saliva, kidneys, genitals, liver, heart muscle, bone tissue, and bronchial secretions. Able to penetrate the blood-brain barrier, it is excreted in breast milk. Metabolism mainly occurs in the liver, it is excreted from the body in feces, a small amount is also excreted in the urine as metabolites and unchanged. The half-life from the body is 5-6 hours, it increases in people suffering from kidney disease.

Use during pregnancy and lactation

Can Lincomycin be used during pregnancy? The fact is that this substance easily penetrates the placental barrier and is concentrated in the blood serum of the unborn child. Moreover, the concentration reaches 25% of the total in maternal blood. For this reason, it is not recommended to use the substance in all cases, except for situations in which the life of the mother in labor depends on the choice.

If you are breastfeeding, the situation is similar. The antibiotic accumulates in breast milk and can cause serious health problems in the baby. Therefore, during treatment, the mother of the baby is transferred to artificial feeding.

Indications for use of Lincomycin

Lincomycin tablets and Lincomycin injections are prescribed for the following diseases:

• diseases of the bones and joints of an infectious nature, the development of which was provoked by microorganisms sensitive to the drug ( osteomyelitis , septic arthritis );
• infectious diseases of the ENT organs and respiratory tract, provoked by sensitive microorganisms (used for sore throat , sinusitis , otitis , bronchitis , pneumonia , tracheitis , etc.);
• diseases of the skin and soft tissues, which are provoked by microorganisms sensitive to the product ( abscess , purulent wounds , mastitis , furunculosis , erysipelas , etc.).
• Lincomycin-AKOS is used externally for inflammatory and purulent diseases of soft tissues and skin, which were caused by microorganisms sensitive to the active ingredient.

Lincomycin is used in dentistry to treat purulent and infectious processes that occur in the oral cavity. In particular, Lincomycin in dentistry can be prescribed for the treatment of periodontitis , periodontitis , gingivitis , purulent abscesses , etc. Whether there are indications for the use of Lincomycin is determined by the dentist individually.

Scope of application

Let's try to figure out what Lincomycin helps with. This medicine is multifunctional and universal. It allows you to fight a huge number of infections and eliminate inflammatory processes in the body. In particular, we are talking about diseases whose development is provoked by streptococci and staphylococci. Lincomycin hydrochloride is most effective in the treatment of diseases such as:

• infectious lesions of joint tissues and bones;
• wound infections;
• boils, phlegmon;
• lung abscess;
• pneumonia;
• empema of the pleura.

The antibiotic lincomycin is used in ENT practice and is effective for sinusitis and other diseases caused by streptococci and staphylococci.

Side effects

When using Lincomycin in ampoules and capsules, patients may experience the following side effects:

• dysfunctions of the gastrointestinal tract ( vomiting , pain, nausea , stool disorders, increased activity of liver enzymes, esophagitis , hyperbilirubinemia );
• disorders of the hematopoietic process ( thrombocytopenia , agranulocytosis , neutropenia , pancytopenia );
• allergic processes ( skin itching , urticaria , rash , swelling erythema multiforme , anaphylactic shock );
• muscle weakness, headaches , arterial hypertension , dizziness .

If you experience any side effects, you should immediately tell your doctor about it.

Lincomycin in dental practice

Lincomycin is very often used in dentistry. After all, it is no secret to specialists that it is staphylococcal and streptococcal infections that lead to complications and purulent inflammation. For many years, Lincomycin hydrochloride has been used effectively:

• for toothache caused by inflammatory (including purulent) processes;
• with osteomyelitis;
• with flux;
• in the treatment of abscesses, treatment of fistula tracts;
• for periodontal disease and gingivitis.

It was the ability to concentrate in bone tissue that made Lincomycin effective for diseases affecting teeth, periosteum, and jaw bone. It also spreads quickly through the blood and lymph fluid, which carry the infection throughout the body.

As you know, the oral cavity is a real breeding ground for bacteria. Some are “local residents” and most often are either safe or opportunistic and become dangerous only during mass reproduction. Such microorganisms are called permanent. Those that come from the outside - with dirty hands, unwashed vegetables, from dishes - are called transient.

Using Lincomycin, it is possible to slow down the development and reproduction of pathogenic and opportunistic flora that are resistant to antiseptics and other types of antibiotics.

The big plus is that microorganisms are neutralized before they have time to develop an addiction to the drug.

Video - Use of lincomycin in dentistry

Instructions for use of Lincomycin (Method and dosage)

If the patient has been prescribed Lincomycin injections, the instructions for use must be carefully followed during the treatment process. The drug in ampoules can be administered intravenously and intramuscularly. The daily dose of the drug for an adult patient should be no more than 1.8 g; if the disease is severe, the doctor can increase it to 2.4 g. The drug is administered three times a day, with the interval between injections being 8 hours. For children, the drug should be administered at a dose of 10-20 mg per 1 kg of body weight per day. Lincomycin is administered intravenously by drip; before administration, the solution is diluted with an isotonic sodium chloride solution.

For infectious diseases, Lincomycin capsules are also prescribed. The instructions for use recommend taking the drug in capsules for sore throat, as well as for sinusitis, either 1 hour before a meal, or 2 hours after taking it. The tablets cannot be chewed, they must be swallowed whole with plenty of liquid. The drug in tablets should be taken at regular intervals, dividing its daily dose. For children whose body weight exceeds 25 kg, the daily dose should be determined at the rate of 30 mg of the drug per 1 kg of weight.

When using the medicine in dentistry, as well as in the treatment of other infectious diseases, as a rule, Lincomycin is prescribed 500 mg three times a day. For severe symptoms, the dose can be increased to 500 mg of the drug four times a day. As a rule, the course of treatment lasts from 1 to 2 weeks. Sometimes the duration of treatment is up to 3 weeks (for example, with osteomyelitis ). If the patient has liver or kidney dysfunction, the dose should be adjusted individually.

Lincomycin ointment is prescribed externally. The instructions for use indicate that Lincomycin-AKOS ointment should be applied directly to the affected area in a thin layer. This procedure must be done 2-3 times a day.

Should I inject into the gums?

If gums are being treated for diseases caused by staphylococcus or streptococcus, Lincomycin is used in a complex of therapeutic measures. Now many periodontists are actively speaking out against this practice. Experts are also inclined to believe that Clindamycin is more effective in periodontal practice. It is also offered by pharmaceuticals in the form of tablets and injections.

Why can't you inject this antibiotic into your gums? On the one hand, it helps to destroy bacteria and eliminate bleeding. On the other hand, it forms a zone of necrosis in the periodontium. That is, a real cemetery of microbes. And this is not an exaggeration. Also, over time, because of this, the area of ​​attachment of the tooth to the bone decreases and, as a result, mobility occurs again.

Usually 1 ml. Lincomycin in the form of a 30% solution was mixed with 0.2 ml. Lidocaine solution 2%. The resulting mixture was administered over 10 days. This combination reduced the toxicity of the drug and the incidence of allergic reactions.

Interaction

If an antibiotic is used at the same time as non-steroidal anti-inflammatory drugs, the patient is more likely to develop respiratory failure and may experience respiratory arrest.

Taking Lincomycin and antidiarrheals simultaneously increases the likelihood of developing pseudomembranous colitis.

You cannot treat with the drug at the same time as using muscle relaxants and inhalational anesthetics.

Antibiotic absorption is reduced when taking adsorbent drugs simultaneously.

Lincomycin reduces the severity of the action of neostigmine , pyridostigmine , ambenonium .

The bacteriostatic effect of the antibiotic is reduced by simultaneous administration of Erythromycin and chloramphenicol .

Pharmaceutical incompatibility with kanamycin , novobiocin , and ampicillin .

Efficiency

There are groups of microorganisms that are resistant to the drug. These are viruses, fungi, some strains of enterococci, gram-negative bacteria and protozoa. On the other hand, this antibiotic is favored by the fact that its use does not lead to the rapid development of resistance. Therefore, repeated courses of application will continue to be effective. This allows for complex drug therapy using antibiotics in injection form and orally.

special instructions

If the patient has impaired renal or liver function, the single dose of the drug is reduced by 1/3-1/2, and the interval between administration is increased. With prolonged antibiotic treatment, the condition of the liver and kidneys must be monitored.

If the patient has renal or liver failure, the drug is contraindicated, for which Lincomycin can be prescribed exclusively for health reasons.

If a patient is prescribed Lincomycin tablets, which subsequently develops pseudomembranous colitis as a side effect, the drug is discontinued and Bacitracin or Vancomycin .

Externally, the ointment is carefully prescribed for dermatomycosis .

The solution should not be administered rapidly intravenously

Summing up

So, having received complete information, we can conclude that this antibiotic is highly effective against staphylococci, streptococci, mycoplasma and a number of other pathogenic microorganisms. Lincomycin is actively used in the treatment of dental diseases caused by various types of infections. It is also an excellent therapeutic agent for topical use in the form of ointments and gels.

One of the advantages of Lincomycin is its affordability. While many, even less effective analogues can cost $10 or more, the injection form of this drug does not exceed $1.5-2. This allows it to be prescribed to most patients, except for those for whom the medicine is contraindicated for individual reasons.

Perhaps you had to treat any disease using injections, capsules or ointments based on it? Don't forget that you can leave comments on our article. We'd love to hear your opinions!

Analogs

Level 4 ATC code matches:
Clindamycin

Lincomycin Hydrochloride

Analogues of the antibiotic Lincomycin are the drugs Lincomycin hydrochloride , Linkocin Clindamycin , Dalatsin C , Clindamycin-Norton , etc.

The use of other drugs by patients prescribed Lincomycin without the prior approval of a physician is strictly prohibited.

With alcohol

When discussing the compatibility of this antibiotic with alcohol, it should be noted that alcohol should not be consumed while being treated with this medicine. This combination will disrupt the absorption of the active substance of the drug in the gastrointestinal tract; under the influence of alcohol on the liver, an acceleration of the half-life of the active substance is observed. Consequently, the concentration of the drug in the body decreases, and its effectiveness decreases.

In addition, if a patient combines Lincomycin and alcohol, the consequences can be negative, as the likelihood of side effects increases.

Lincomycin for dental diseases

Scientists have discovered that 30 species of local flora live in periodontal tissues. These are bacteria that do not harm the body. About 300 more species are transient. Such microorganisms penetrate in two ways - through lymph and blood or through the canals of teeth damaged by caries. Usually the patient pays attention to the problem late - when toothache begins, swelling of the gums appears next to the painful tooth.

The drug is actively used in the treatment of various dental diseases of infectious origin to stop purulent inflammatory processes that can damage the bone tissue of the jaw. Lincomycin is one of the most effective agents that stop the development of pathogenic microorganisms. It inhibits the production of proteins in the bacterial cell.

Periodontitis, purulent abscesses and other complications of previously untreated caries are eliminated much faster thanks to the active action of Lincomycin against infectious agents.

Video - Antibiotics in dental treatment

Reviews about Lincomycin

Reviews of Lincomycin that users leave online indicate that this drug has a pronounced antimicrobial effect and allows you to quickly get rid of the unpleasant symptoms of infectious diseases. Those who have used Lincomycin injections also leave mostly positive reviews.

Both when administered intravenously and intramuscularly, the solution acts quickly and reduces the severity of symptoms. Reviews about the use of the product in dentistry often contain information that the drug helped to quickly get rid of purulent and inflammatory diseases.

People's opinions and the real situation

We tried to find reviews on the Internet about real experience of use. And these should have been not just reports from doctors who “everything is according to plan,” but a “living text”, a story about how it really happens. After all, you and I already know that injections into the gums can cause negative consequences. For example, often after wisdom teeth are removed, doctors prescribe Lincomycin capsules to prevent possible complications. We found several reviews of such patients. They talked about their experience using the medicine. Overall, most did not experience any problems or side effects. The only symptom that develops in a large percentage of people is candidal stomatitis. You need to be prepared for the fact that thrush may develop. But these consequences are generally removable.

As expected, I received a negative comment about gum treatment. It is interesting that here we are not talking about necrotic damage to the tissues that hold the tooth, but about banal side effects - nausea, vomiting, diarrhea. Even probiotics taken at the same time did not help. Still, the drug is very powerful. And if such individual reactions occur, it makes sense to replace it with another, for example, Clindomycin and analogues.

5 lincomycin analogues:

How does an experienced doctor act? He weighs the pros and cons of using each medicine. That is, it determines how much the benefits of its use exceed the theoretical harm from side effects. Here the choice is influenced by the patient’s age, condition, etc. It is unlikely that Lincomycin will be used for an infant or a pregnant woman.

Lincomycin price, where to buy

The price of Lincomycin in ampoules averages from 40 rubles for 10 ampoules of 1 ml.

The price of Lincomycin tablets ranges from 60 to 90 rubles for 20 pieces. You can buy the drug in capsules in Ukraine for an average of 25 UAH. (30 pcs.).

Lincomycin-AKOS ointment can be purchased at a price of 27 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Lincomycin capsules 250 mg 20 pcs. Ozone LLC
  126 rub. order
• Lincomycin hydrochloride solution for injection. 30% 1ml 10 pcs. JSC Dalkhimfarm

  113 RUR order

Pharmacy Dialogue

• Lincomycin (caps. 250 mg No. 20) Belmedpreparaty

  68 RUR order

• Lincomycin hydrochloride (amp. 30% 1 ml No. 10) Belmedpreparaty

  90 rub. order

• Lincomycin (caps. 250 mg No. 20) Ozon LLC

  120 rub. order

• Lincomycin h/x (caps. 250 mg No. 20)Production of medicines

  64 RUR order

• Lincomycin hydrochloride (amp. 30% 1 ml No. 10) DHF JSC

  91 rub. order

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Pharmacy24

• Lincomycin-Darnitsa 30% 1 ml No. 10 solution
  37 UAH. order
• Lincomycin KMP 250 mg N30 capsules PAT "Kievmedpreparat", Ukraine

  35 UAH order

• Lincomycin-Darnitsa 30% 2 ml No. 10 solution for injection

  54 UAH order

• Lincomycin 300 mg/ml 1 ml No. 10 solution TOV" Pharmaceutical company "Zdorovya", Kharkiv, Ukraine

  34 UAH order

• Lincomycin 0.25 N20 capsules PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine

  32 UAH order

PaniPharmacy

• Lincomycin capsule Lincomycin capsules 0.25g No. 30 Ukraine, Kievmedpreparat OJSC

  42 UAH order

• LINCOMYCIN ampoule Lincomycin solution for injection 30% ampoule 1 ml No. 10 Ukraine, Health LLC

  35 UAH order

• Lincomycin ampoule Lincomycin solution for injection 30% ampoule 1 ml No. 10 Ukraine, Darnitsa ChAO

  41 UAH order

• LINCOMYCIN ampoule Lincomycin solution for injection 30% ampoule 2ml No. 10 Ukraine, Health LLC

  53 UAH order

• Lincomycin ampoule Lincomycin solution for injection 30% ampoule 2ml No. 10 Ukraine, Darnitsa ChAO

  56 UAH order

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Compound

It is a crystalline substance with a bitter taste produced by Streptomyces lincolnensis and other streptomycetes and actinomycetes. That is, it is a product of bacterial origin. The substance is water-soluble, but poorly soluble in alcohol. When making tablets, excipients are added to the composition. Formula - C18H34N2O6S.

Release forms

• injections (injection solution in ampoules);
• capsules and tablets;
• lincomycin ointment, Lincocel gel.

This antibiotic is usually sold in pharmacies with a prescription. In different countries, drugs are produced that are based on this substance, but are called differently.