Progesterone injections to induce menstruation

Almost every woman faces such a problem as a violation of the monthly cycle.

Not only stress and diseases of the genitourinary system, but also changes in diet, changes in climatic conditions, and taking certain groups of medications can lead to a delay in critical days.

To normalize the monthly cycle for patients, doctors prescribe Progesterone in the form of intramuscular injections.

How do they influence

Progesterone injections to provoke menstruation help get rid of painful sensations in the lower part of the peritoneum that accompany menstruation. The drug not only relieves intensity, but also completely relieves pain.

In the body of each woman, the remedy for inducing menstrual periods behaves differently. That is why the effectiveness of hormonal therapy will directly depend on the psycho-emotional mood, general well-being, and individual characteristics.

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How to inject progesterone

Before you start using Progesterone to induce menstruation, women need to take tests and undergo an examination. After this, the specialist must determine the phase of her menstrual cycle and calculate the amount of the hormone.

A set of measures will allow the doctor to calculate the dosage of Progesterone as accurately as possible.

Injections to induce menstruation should be given intramuscularly, but subcutaneous administration is also allowed. Before manipulation, the ampoule should be held in the palm of your hand so that it reaches the desired temperature (within 40 degrees).

After this, the spout of the ampoule breaks off, the medicine is drawn into a syringe and injected into the muscle tissue. As soon as the needle is removed, the injection site must be wiped with alcohol to prevent infection.

Detailed description of the study

Progesterone is a female steroid hormone produced by the corpus luteum of the ovaries and, during pregnancy, by the placenta. The concentration of progesterone in the blood is determined to confirm or exclude ovulation during the menstrual cycle. The maximum concentration of progesterone is observed in the luteal phase of the cycle.

Produced by the corpus luteum of the ovaries. A progesterone test is prescribed to identify the causes of infertility, determine the presence of ovulation, diagnose an ectopic or pathological pregnancy, and to monitor the condition of the fetus and placenta during pregnancy in the presence of complications. The main function of the hormone estradiol is to prepare a woman’s body for pregnancy. Each month, estrogen causes the inner lining of the uterus, the endometrium, to grow and renew itself, while luteinizing hormone (LH) causes one of the ovaries to release an egg. In place of the released egg, the so-called corpus luteum is formed, which produces progesterone. Progesterone, together with the hormone secreted by the adrenal glands, stops the growth of the endometrium and prepares the endometrium of the uterus for the implantation of a fertilized egg, and after its implantation helps to maintain pregnancy: it suppresses the activity of the smooth muscles of the uterus, maintains the dominance of pregnancy in the central nervous system; stimulates the development of the terminal secretory sections of the mammary glands and the growth of the uterus, the synthesis of steroid hormones; has an immunosuppressive effect, suppressing the reaction of rejection of the fertilized egg. Stimulates sebum secretion. If fertilization does not occur, the corpus luteum disappears, progesterone levels drop and menstrual bleeding occurs. If the fertilized egg attaches to the wall of the uterus, the corpus luteum continues to produce progesterone. After a few weeks, the placenta takes over the function of the corpus luteum to produce progesterone, being the main source of this hormone during pregnancy.

An increase in progesterone concentration occurs during pregnancy, tumors of the adrenal glands and testicles, hydatidiform mole, and ovarian chorionepithelioma. A decrease in hormone levels occurs when there is a threat of miscarriage, galactorrhea-amenorrhea syndrome, taking oral contraceptives and certain medications.

Dosage of the drug

To provoke menstruation, women may be prescribed injections of Progesterone in the following concentration:

1,00%;
2,00%;
2,50%.

Injections should be given daily at 5 mg, or once every two days at 10 ml.

The duration of therapy is approximately six days, but in the absence of menstruation it can be extended to 8-10 days.

Application

Menstruation and progesterone are interconnected. Without a sufficient amount of the hormone, KD will not occur. To prevent side effects, the dosage of the drug is prescribed by the doctor. After measuring the concentration of the hormone, the attending doctor chooses in what concentration the medicine should be prescribed to the patient: 1%, 2%, 2.5%.

The injection solution is administered intramuscularly or subcutaneously. Before use, the ampoule is slightly warmed in your hands or in a water bath to 40°C. If crystals are visible, then the medicine is kept in a water bath until they are completely dissolved.

Since critical days may be absent for various reasons, treatment regimens differ. Before inducing menstruation, progesterone for amenorrhea begins treatment with medications containing the hormone estrogen. It should provoke proliferation of the inner uterine lining.

Only then is Progesterone administered to induce menstruation. The medication is used according to a specific scheme. How to induce menstruation with progesterone during amenorrhea? The medicine is started to be administered immediately after a course of estrogen. Inject 5 mg daily or 10 ml every other day. The duration of therapy is 6–8 days.

If the MC is disturbed, and the woman notices severe pain in the lower abdomen, injections of this drug are also prescribed. Injections of Progesterone 2.5% to induce menstruation help get rid of pain; the drug not only reduces the severity, but completely eliminates pain.

Progesterone in ampoules to induce menstruation in anemia is prescribed after completing the appropriate course of treatment. The duration of therapy is no more than 10 days, injections of the drug should be given for at least 6 days, and the dose of a 1% solution is about 1 ml.

Progesterone injections are used to induce menstruation if CD does not occur within 40 days and the test shows a negative result. If the delay is less than 5 days, treatment with medications is not carried out. Hormonal therapy in the absence of CD lasts from 1 to 2 weeks, injections or tablets may be prescribed.

Progesterone 2.5% to induce menstruation instructions:

injections are given in phase 2 of the MC;
The injection is given daily, you need to choose one time so as not to disturb the order;
the injection should be carried out in a dose of 1 ml of 1% or 0.5 ml of 2.5%.

An important condition is that only a medical professional knows how to inject Progesterone when menstruation is late; it is recommended to either find out how to do it yourself or come to the manipulation room every day to carry out the procedure. It is better if the injection is given by a nurse, since complications may occur if the solution is administered incorrectly.

Injections

Some women have to travel too long to get to the hospital, are unable to undergo inpatient treatment, or have other valid reasons that require Progesterone injections to be given at home. To avoid the development of complications, the injection is given according to a certain scheme.

Progesterone injections to induce menstruation - instructions for use at home:

the ampoule of solutions is heated in the hands;
then they wash their hands and put on medical gloves, you can use ordinary ones - not sterile ones;
Before opening, the base of the ampoule and the injection site of the solution are wiped with alcohol (use different swabs);
Now you can fill the syringe with medicine and release the air;
the medication Progesterone is injected into the upper part of the buttock, holding the needle at a right angle.

After the procedure, cotton wool soaked in alcohol is applied to the injection site to prevent infection and stop the bleeding.

Contraindications for use

Before you start injecting Progesterone, you need to carefully study the instructions, in which the manufacturer of the drug indicates all the contraindications:

presence of bleeding;
epileptic seizures;
depression;
liver pathologies;
diabetes;
thrombosis;
presence of tumors in the breast.

Attention! If a married couple plans to conceive a child soon, then the woman should take the drug Progesterone in doses to induce menstruation.

Side effects

Progesterone injections in the absence of CD can provoke the occurrence of a post-injection abscess. It is characterized by purulent inflammation deep in the muscle tissue. Treatment of the disease is carried out only by surgery.

The formation of oleoma, pressure surges, rapid pulse, headaches and migraines, decreased libido, weight gain, and dizziness are also possible. In case of an overdose of the drug, swelling, shortness of breath occur in the body, and an allergic reaction may occur.

Women who use Progesterone for delayed periods (injections) leave mostly positive reviews. They note that already on the 5th–6th day of use, the long-awaited menstruation occurs.

According to reviews of Progesterone to induce menstruation, we can conclude that it is better to administer the medicine intramuscularly rather than subcutaneously. This is due to the fact that the pain syndrome is less pronounced with intramuscular injection of the injection solution.

Possible side effects

Injections can cause a number of side effects:

A post-injection abscess will occur, which can only be eliminated surgically.
Oleoma will develop, accompanied by migraines, rapid pulse, pressure surges, weight gain, dizziness, and decreased libido.
An overdose, in which the patient may experience shortness of breath, an allergic reaction, and swelling.
Pigment spots will appear on the skin.
The functionality of the liver will be impaired.
There will be discomfort in the mammary glands.

Attention! If a woman uses Progesterone incorrectly, her period may be delayed for several more cycles.

Utrozhestan capsules 200 mg 14 pcs ➤ instructions for use

Utrozhestan should not be used for contraception.

The drug should not be taken with food, because food intake increases the bioavailability of progesterone.

Patients with a history of depression should be monitored, and if severe depression develops, the drug should be discontinued.

Patients with concomitant cardiovascular diseases or a history of them should also be periodically observed by a doctor.

The use of the drug Utrozhestan after the first trimester of pregnancy can cause the development of cholestasis.

During long-term treatment with progesterone, regular medical examinations (including liver function tests) should be performed, and treatment should be discontinued if abnormal liver function tests or cholestatic jaundice occur.

When using progesterone, it is possible to reduce glucose tolerance and increase the need for insulin and other hypoglycemic drugs in patients with diabetes mellitus.

If amenorrhea occurs during treatment, pregnancy must be excluded.

If the course of treatment begins too early in the menstrual cycle, especially before the 15th day of the cycle, shortening of the cycle and/or acyclic bleeding is possible. In case of acyclic bleeding, the drug should not be used until the cause is determined, including a histological examination of the endometrium.

If there is a history of chloasma or a tendency to develop it, patients are advised to avoid UV irradiation. More than 50% of cases of spontaneous abortions in early pregnancy are caused by genetic disorders. In addition, the cause of spontaneous abortions in early pregnancy can be infectious processes and mechanical damage. The use of the drug Utrozhestan in these cases can only lead to a delay in rejection and evacuation of a non-viable fertilized egg.

The use of the drug Utrozhestan to prevent threatened abortion is justified only in cases of progesterone deficiency.

Utrozhestan contains soy lecithin, which can cause hypersensitivity reactions (urticaria and anaphylactic shock).

When carrying out HRT with estrogens during perimenopause, it is recommended to use the drug Utrozhestan for at least 12 days of the menstrual cycle.

With a continuous HRT regimen in postmenopause, it is recommended to use the drug from the first day of taking estrogen.

When carrying out HRT, the risk of developing venous thromboembolism (deep vein thrombosis or pulmonary embolism), the risk of ischemic stroke, and coronary artery disease increases. Due to the risk of thromboembolic complications, you should stop using the drug if: - visual disturbances such as loss of vision, exophthalmos occur , double vision, vascular lesions of the retina, migraine, venous thromboembolism or thrombotic complications, regardless of their location.

If there is a history of thrombophlebitis, the patient should be closely monitored.

When using Utrozhestan with estrogen-containing drugs, you must refer to the instructions for their use regarding the risks of venous thromboembolism. The results of the Women Health Initiative Study (WHI) clinical trial indicate a slight increase in the risk of breast cancer with long-term, more than 5 years, combined use of estrogen-containing drugs with synthetic drugs gestagens. It is not known whether there is an increased risk of breast cancer in postmenopausal women when taking HRT with estrogen-containing drugs in combination with progesterone. The results of the WHI study also revealed an increased risk of developing dementia when starting HRT over the age of 65 years. Before starting HRT and regularly during it carrying out the woman should be examined to identify contraindications to its implementation. If clinically indicated, a breast examination and gynecological examination should be performed.

The use of progesterone may affect the results of some laboratory tests, including liver function, thyroid function, coagulation parameters, and pregnanediol concentrations.

Impact on the ability to drive vehicles and operate machinery

When using the drug orally, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Description of the drug

The main active component is similar to the endogenous female hormone. It affects formations on the uterine mucosa and prevents the endometrium from increasing in volume. Experts recommend taking a hormonal drug for patients diagnosed with progesterone deficiency, which is why a woman cannot become pregnant or bear a child.

Also, low levels of this hormone cause PMS, absence of a monthly cycle, bleeding, dysmenorrhea and amenorrhea. The hormonal drug suppresses the production of estrogen, it is prescribed to stop bleeding, as well as to preserve the fetus.

Composition of tablets

The active substance is Dydrogesterone - 10 mg. The component is not a contraceptive. Film-coated pills are effective when taken orally. The line on the tablet is not intended to separate doses, but is only needed to break the pill and make it easier to swallow. The composition also contains excipients: starch, lactose monohydrate, hypromellose, silicon dioxide and magnesium stearate. Pros of dydrogesterone-based tablets:

does not change metabolic processes in the body;
has no glucocorticoid and estrogenic effects;
does not affect follicular ovulation;
there are no side effects that may occur as a result of treatment with synthetic progestins;
does not change temperature when determining ovulation;
helps normalize blood composition.

When using Duphaston, the speed of psychomotor reactions does not change, the tablets do not affect concentration. You can operate machinery and vehicles, but after taking it you may experience slight dizziness or confusion.

Identical drugs

Hormonal tablets that have a similar effect include the medications Duphaston and Dydrogesterone. Duphaston was produced by another pharmaceutical manufacturer. It has a slight difference in additional substances and a slightly lower cost.

Dydrogesterone is the most complete analogue in its pure form, replenishing the deficiency of endogenous progesterone. Its cost is slightly lower than Duphaston, and it has a minimum of additional components. These drugs contain the same component and differ from the analogue in name, so their action and contraindications are similar to Duphaston. These medications can replace the original without danger to the body.