Mexidol: Instructions for use: Description of the drug: Price for EUROLAB

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Manufacturers: Armavir biofactory, Ellara MC, RKNPK Rosmedtekhnologii

Active ingredients

Ethylmethylhydroxypyridine succinate

Disease class

Mild cognitive impairment
Post-concussion syndrome
Mental and behavioral disorders caused by alcohol consumption - withdrawal state
Anxiety disorder, unspecified
Transient transient cerebral ischemic attacks [attacks] and related syndromes
Autonomic nervous system disorders
Toxic encephalopathy
Encephalopathy, unspecified
Brain infarction
Hypertensive encephalopathy
Cerebrovascular disease, unspecified
State of emotional shock and stress, unspecified
Malaise and fatigue
Intracranial trauma
Consequences of intracranial injury
Antipsychotic and neuroleptic drugs

Clinical and pharmacological group

Not indicated. See instructions

Pharmacological action

Antioxidant

Pharmacological group

Means for correcting disorders of alcoholism, toxicity and drug addiction
Antihypoxants and antioxidants

Solution for injection Mexidol (Mexidolum)

Instructions for medical use of the drug

Description of pharmacological action

Indications for use

- acute cerebrovascular accidents; — TBI, consequences of TBI; - encephalopathy; — vegetative dystonia syndrome; — mild cognitive disorders of atherosclerotic origin; - anxiety disorders in neurotic and neurosis-like conditions; — relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders; - acute intoxication with antipsychotic drugs; - acute purulent-inflammatory processes in the abdominal cavity (acute necrotizing pancreatitis, peritonitis) - as part of complex therapy.

Release form

Solution for injection 5% 1 amp. Mexidol in 2 ml ampoules, 5 ampoules in a blister pack; in a cardboard pack 2 packs. Solution for injection 1 amp. Mexidol 50 mg in ampoules of 2 or 5 ml, in a blister pack 5 ampoules; in a cardboard pack 2 packs.

Pharmacodynamics

Mexidol has antihypoxic, membrane protective, nootropic, anticonvulsant, anxiolytic effects, and increases the body's resistance to stress. The drug increases the body's resistance to the effects of major damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, intoxication with alcohol and antipsychotic drugs - antipsychotics). Mexidol improves cerebral metabolism and blood supply to the brain, microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the level of total cholesterol and LDL. Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis. The mechanism of action of Mexidol is due to its antihypoxic, antioxidant and membrane protective effects. It inhibits the processes of lipid peroxidation, increases the activity of superoxide oxidase, increases the lipid-protein ratio, reduces the viscosity of the membrane, and increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, improves the transport of neurotransmitters and synaptic transmission. Mexidol increases dopamine levels in the brain. Causes an increase in the compensatory activity of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions, with an increase in the content of ATP, creatine phosphate and activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

Pharmacokinetics

When administered intramuscularly, the drug is detected in the blood plasma for 4 hours after administration. Cmax when administered in doses of 400–500 mg is 3.5–4.0 mcg/ml, Tmax is 0.45–0.50 hours. Mexidol quickly passes from the bloodstream into organs and tissues and is quickly eliminated from the body. The drug retention time (MRT) is 0.7–1.3 hours. Mexidol is excreted from the body in the urine, mainly in glucurone-conjugated form and in small quantities unchanged.

Use during pregnancy

Contraindicated during pregnancy. During treatment, breastfeeding should be stopped (adequate and strictly controlled clinical studies of the safety of the drug Mexidol during pregnancy and breastfeeding have not been conducted).

Contraindications for use

- increased individual sensitivity to the drug; - acute renal dysfunction; - acute dysfunction of the liver. Strictly controlled clinical studies of the safety of the drug Mexidol in children, pregnancy and breastfeeding have not been conducted.

Side effects

Nausea and dry mouth, drowsiness, and allergic reactions may occur.

Directions for use and doses

IM or IV (stream or drip). For intravenous administration, water for injection is used as a solvent. Mexidol is administered in a stream over 5–7 minutes, and dropwise at a rate of 60 drops per minute. Doses are selected individually. Begin treatment with a dose of 0.05–0.1 g 1–3 times a day, gradually increasing the dose until a therapeutic effect is obtained. The duration of treatment and the choice of individual dose depend on the severity of the patient’s condition and the effectiveness of treatment. The maximum daily dose should not exceed 0.8 g. For the treatment of atherosclerotic dementia in elderly patients, Mexidol is prescribed IM at a dose of 0.1–0.3 g/day. In case of acute intoxication with neuroleptics, the drug is administered into a vein at a dose of 0.5–0.3 g/day. In the complex treatment of acute purulent-inflammatory processes of the abdominal cavity (acute destructive pancreatitis, peritonitis), Mexidol is prescribed in a single dose of 200 mg 3 times a day. In case of severe disease, the drug is diluted in 200 ml of physiological 0.9% sodium chloride solution and administered at a rate of 40–60 drops per minute. For milder cases of the disease, Mexidol is administered intramuscularly. The course of treatment is 3–10 days.

Overdose

In case of overdose, drowsiness may develop.

Interactions with other drugs

Enhances the effect of benzodiazepine anxiolytics (phenazepam, diazepam), anticonvulsants (carbamazepine) and antiparkinsonian drugs (levodopa). Reduces the toxic effects of ethyl alcohol.

Precautions for use

Patients with blood pressure above 180/100 mmHg, a crisis course of arterial hypertension and severe affective instability require careful monitoring of blood pressure during Mexidol therapy. Use with caution while working for vehicle drivers and people whose profession involves increased concentration.

Special instructions for use

In some cases, especially in predisposed patients with bronchial asthma with increased sensitivity to sulfites, severe hypersensitivity reactions may develop.

Storage conditions

List B.: In a place protected from light.

Best before date

24 months

ATX classification:

N Nervous system

N07 Other drugs for the treatment of diseases of the nervous system

N07X Other drugs for the treatment of diseases of the nervous system

N07XX Other drugs for the treatment of diseases of the nervous system

MEXIDOL (solution)

And then, if Mexidol, according to the instructions, can be taken for an ordinary hangover, then this speaks for itself - Mexidol can be taken without a doctor’s prescription.
To begin with, I purchased 10 ampoules of 2 ml for injection. This is what they look like.

I’ll tell you in more detail about the problems with my health so that I have an overall picture:

I have been suffering from low blood pressure for a long time, which is accompanied by weakness, drowsiness and a generally depressed state. And this summer I also suffered from other ailments arising from this problem of dilated blood vessels - hyposkia (lack of oxygen), varicose veins. The weakness was so terrible, my head was hard to think, I was dizzy, I constantly wanted to sleep, there was not enough oxygen, and sometimes it even seemed like I was about to lose consciousness.

After looking at the effect the drug had on my mother, I decided to start a course of Mexidol injections for myself. From the first injection I felt relief. After the first injection, after a couple of hours, my head became clear, not like from coffee, but I felt energetic in a natural way. All the symptoms described above went away for me, but not without the help of the venotonic drug Phlebodia, if we talk about problems with my legs.

With Mexidol it became easier to breathe and my brain began to work better. This drug did not cause me insomnia or increased agitation, I just felt a natural surge of energy. I could get out of bed in the morning with ease and in a good mood.

But as it turned out, 10 injections were not enough and after finishing taking Mexidol, a week later my previous health problems began to return in the form of lethargy and drowsiness. Then I decided to repeat the course of 10 more injections. And this gave me a long-lasting effect, which still lasts - about 3 months already.

On my own behalf, I can also add that it is better to take the drug in the form of injections - they are not so difficult to give to yourself. It seems to me that in tablet form it will not be as effective as in injections. The injections are a little painful, but the result is worth it.

Also, as far as I know, Mexidol can enhance the effect of drugs taken in parallel. I think that in my case this was the case - when I took the venotonic Phlebodia, my legs quickly stopped hurting and swelling.

In general, Mexidol is an excellent drug that does not give side effects, only positive ones. Gives strength, relieves dizziness and weakness, improves cerebral circulation. To consolidate the effect of hypotension, you need to lead a healthy lifestyle - spend more time in the fresh air, do more physical activity, at least walk. I am grateful to Mexidol for restoring my life and recommend it. But you still need to consult a doctor before taking this drug.

PS Recently I had to test Mexidol as a hangover reliever. I had no doubt that he would help. And so it turned out. A friend of mine needed to eliminate a hangover after a drunken party, and I offered him an injection with Mexidol. We took a couple of 2 mg injections and the hangover went away. This thing happened before my eyes. This morning the man was drunk, but after the injections he began to come to his senses. The headache went away and mental sobriety appeared. Coordination of movements was also restored. After 3-4 hours, this, so to speak, patient was already fresh and cheerful as a cucumber, as if nothing had happened. So Mexidol is also great as an anti-hangover remedy.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Mexidol, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Mexidol is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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