Instructions for use SUPRASTIN®

Release form

The medicine has 2 forms: tablets 25 mg and solution d/i 20 mg/ml.

Suprastin tablets are disc-shaped, grayish-white or white. The name “SUPRASTIN” is engraved on one side and a line on the other. The smell is weak or completely absent. The tablets are packaged in blisters of 10 pieces, 2 blisters in a package.

The aqueous solution is transparent and colorless, with a slight specific odor. Available in ampoules with a capacity of 1 ml, package No. 5.

Pharmacodynamics and pharmacokinetics

The active substance of Suprastin is a chlorinated analogue of tripelenamine and belongs to the group of 1st generation antihistamines sedatives .

histamine receptors . Studies (both preclinical and clinical) prove its effectiveness in hay fever and other allergic diseases .

Like other H1 blockers, the action of the drug is aimed mainly at preventing immediate hypersensitivity reactions, and in cases where the reaction has already begun to develop, at preventing further histamine .

Experiments on guinea pigs showed that even in a very low dosage, the drug protected animals from the effects of histamine at a dose 120 times higher than the lethal dose.

Chlorpyramin also affects the central nervous system, capillary permeability and smooth muscle.

Absorption from the digestive canal after taking the required dose is rapid. The effect is observed 15-30 minutes after taking the tablet, reaches its maximum within 1 hour and lasts for up to 6 hours.

Chlorpyramin metabolized in the liver. Metabolic products are excreted mainly by the kidneys. Moreover, the drug is eliminated from the body of a child faster than from the body of an adult.

In patients with renal dysfunction, the elimination of chloropyramine may be reduced. With liver dysfunction , the metabolism of the substance slows down, which requires changing the dose of the drug.

Pharmacological properties of the drug Suprastin

Suprastin belongs to the group of antihistamines, histamine H1 receptor blockers. Prevents the development and facilitates the course of allergic reactions. In addition to antiallergic, it has a pronounced sedative, hypnotic and antipruritic effect. It has peripheral anticholinergic activity and moderate antispasmodic properties. The mechanism of action of the drug is to block histamine H1 receptors. After oral administration, it is quickly absorbed into the gastrointestinal tract. Suprastin solution is well distributed in the body. The maximum concentration in the blood is achieved 1–2 hours after administration; The therapeutic level of concentration lasts 3–6 hours. It is intensively metabolized in the liver. The half-life is about 14 hours. Eliminated through the kidneys and intestines.

Indications for use: what are Suprastin tablets and solution used for?

Suprastin tablets - what are they for?

Suprastin tablets are used in allergology:

• for the treatment of urticaria and allergies (nutritional or caused by insect bites), hay fever , serum sickness , allergic rhinopathy , dermographism , itching, conjunctivitis ;
• as an adjuvant for angioedema and systemic hypersensitivity reactions of the anaphylactic type .

The drug can also be prescribed to reduce swelling of the mucous membrane of the middle ear and nose during infections of the ENT organs ( sinusitis , otitis media ).

The combination “Suprastin - No-shpa - Analgin ” is used to reduce persistent hyperthermia . Suprastin ( antihistamine ) relieves swelling of the mucous membrane, No-shpa ( antispasmodic ) relieves spasms and promotes vasodilation, Analgin ( analgesic-antipyretic ) helps reduce temperature.

What does Suprastin in solution form help with?

Indications for the use of Suprastin in the form of a d/i solution are the same as for the tablet form of the drug.

What are the tablets used for?

Suprastin is produced in ampoules and tablets. In the form of injections, this medicine is used mainly in hospital settings, when it is necessary to eliminate severe manifestations of allergies (loss of consciousness, anaphylactic shock). Therefore, Suprastin tablets are most often purchased for the home first aid kit. What do they help with? Indications for their use are:

• rhinitis and conjunctivitis of allergic origin;
• contact dermatitis;
• hives;
• pathological reaction to medications, foods, insect bites, UV radiation.

What else does Suprastin help with? This antihistamine will help eliminate the characteristic signs of allergies: itching, cough, rash, swelling, low blood pressure - in other words, relieves its most painful symptoms. If you find Suprastin at home, then it is advisable to use it for infectious lesions of the ENT organs, which are accompanied by otitis media and a severe runny nose. This medicine will quickly relieve swelling in the nose and restore nasal breathing. Suprastin is given to children after vaccination, and to adults after tooth extraction. Also, do not forget that Suprastin should be given along with an antipyretic at high temperatures.

Contraindications

Contraindications for Suprastin:

• acute asthma ;
• stomach ulcer;
• angle-closure glaucoma;
• treatment with MAO inhibitors;
• arrhythmia;
• acute myocardial infarction;
• prostate hyperplasia;
• urinary retention;
• hypersensitivity to ethylenediamine ;
• allergy to the drug.

Side effects

Side effects of Suprastin from the central nervous system: increased fatigue, sedation , ataxia , dizziness , convulsions, tremor , headache, encephalopathy , decreased visual clarity, euphoria, drowsiness, impaired psychomotor functions.

From the cardiovascular system, arrhythmia , tachycardia , and arterial hypotension . From the digestive system: discomfort and pain in the epigastrium , dry mouth, diarrhea, nausea, vomiting, increased symptoms of gastroesophageal reflux , increased or complete lack of appetite.

On the part of the blood system, in rare cases, pathological changes in the blood may be observed (for example, agranulocytosis , hemolytic anemia , leukopenia , thrombocytopenia etc.).

From the organs of vision: ocular hypertension , glaucoma .

From the urinary system and kidneys: urinary retention, dysuria .

From the subcutaneous tissue and skin: hypersensitivity reactions, as well as a painful reaction to sunlight.

From the musculoskeletal system: myopathy .

Reactions of the immune system to the use of the drug can be expressed in the form of skin itching, rash, skin hyperemia, urticaria , angioedema .

Other side effects: changes at the injection site of the d/i ​​solution.

Instructions for use of Suprastin

Suprastin tablets: instructions for use. How to take Suprastin for adults?

The tablets should be taken with food, without crushing or chewing, and with liquid.

For adults, Suprastin tablets are prescribed to be taken at a dose of 75-100 mg/day. Exceed the dose of 100 mg/day. contraindicated.

Treatment is considered complete when all clinical symptoms are eliminated. If the above adverse reactions develop, the medication should be stopped.

How to take Suprastin if you have allergies if the disease is severe?

In acute severe conditions or anaphylactic shock, treatment begins with intravenous administration of the drug (intravenous injection should be performed very slowly). Subsequently, they switch to injecting the solution into the muscle or taking tablets.

The duration of use for severe allergies

Instructions for use of Suprastin in ampoules

Suprastin injections can only be given by a nurse or doctor.

The dosage of Suprastin for an adult is usually 1-2 ml/day. The drug is injected into the muscle. In especially severe cases, treatment begins with intravenous injections.

In case of liver dysfunction due to a decrease in the metabolism of the active substance, the patient may require a dose adjustment towards its reduction. A dose reduction is also necessary for patients with renal dysfunction , which is associated with the participation of this organ in removing chloropyramine from the body.

How many days should adults take Suprastin?

The duration of treatment depends on the severity of allergy and the body's sensitivity to chloropyramine . As a rule, the medicine is taken in short courses (5-7 days) when the process worsens. In case of severe disease, the doctor may make other prescriptions.

It should be remembered that with prolonged use of the drug, the patient may develop addiction to it.

Instructions for use of Suprastin for children

For children, the drug is prescribed for allergic reactions to medications, insect bites, food, eczema , taxidermy , urticaria , dermatitis , neurodermatitis and a number of other allergic diseases.

The use of Suprastin is also advisable for chickenpox : the drug can reduce the intensity of itching and somewhat calm the child’s nervous system.

Before giving Suprastin to children, you should read the list of contraindications. The use of tablets is contraindicated in children under 3 years of age; the solution is not prescribed to newborn infants (including premature infants).

In addition, you should not give the medicine in any form during an acute attack of asthma , intolerance to chloropyramine or any of the auxiliary components.

The manufacturer does not produce special children's Suprastin with a lower dosage of the active substance. There are no other dosage forms (ointment, drops, syrup) except tablets and solution.

How should children take Suprastin tablets?

Dosage of Suprastin for children under 6 years of age: 1 tablet/day, divided into 2 doses. According to the instructions, for children 6-14 years old the dose is 1-1.5 tablets/day. (0.5 tablets at each dose).

Depending on the body's response to treatment, the dose can be increased if necessary. The highest dose for a child is 2 mg/kg/day.

For infants, Suprastin tablets are prescribed, if necessary, 1/4-1/5 tablet. 2 rubles/day..

The solution, like the tablets, is dosed depending on the patient’s age: children under one year of age are administered 0.25 ml at the initial stages of treatment, children aged 12 months to 6 years - 0.5 ml, children aged 6- 14 years - from 0.5 to 1 ml.

Suprastin is contraindicated for newborns (including newborns born prematurely).

Injections are given with an insulin syringe with a needle for intramuscular injection. The maximum permissible dose of the drug is 2 mg/kg/day.

Analgin, No-shpa, Suprastin: interaction

This mixture, also called a “triad,” is a combination of three medications:

• Analgesic antipyretic medication, which is usually Analgin. It can be replaced with Paracetamol or one of the drugs containing ibuprofen.

• An antihistamine, which is most often Suprastin. It could also be Diphenhydramine.
• An antispasmodic, which is mainly used as No-shpu. This medicine can also replace Papaverine.

If you mix medications such as Analgin, No-shpa and Suprastin in one syringe, you will get a lytic mixture. The combination of these medications leads to rapid and safe stabilization of temperature. In this case, Analgin has an analgesic and antipyretic effect, No-shpa relieves spasms, and Suprastin has an antihistamine effect. Please note that the lytic combination is prescribed for fever, when the patient does not have a fever, but chills. The combination of 3 drugs that have antihistamine, antipyretic and antispasmodic effects is called a lytic mixture. Intramuscular administration of this composition helps to quickly normalize the temperature.

Overdose

Accidental or intentional overdose, especially in children, can cause death.

atropine poisoning . They are expressed in the form:

• anxiety;
• hallucinations;
• athetosis;
• ataxia;
• seizures;
• impaired coordination of movements.

In young children, excitement predominates.

In some cases sinus tachycardia , dry mouth, facial flushing, fixed dilated pupils, fever, and urinary retention occur.

In adults, facial flushing and fever are observed intermittently, with periods of agitation followed by convulsive seizures and postconvulsive depression. The patient develops coma , cardiac and respiratory failure . Death occurs within 2-18 hours.

Cardiorespiratory monitoring as well as symptomatic therapy are recommended. Suprastin does not have a specific antidote.

Suprastin drug overdose, symptoms and treatment

Symptoms: in children - agitation, anxiety, hallucinations, ataxia, athetosis, convulsions, mydriasis and immobility of the pupils, flushing of the facial skin, hyperthermia; then - vascular collapse, coma. In adults - lethargy, depression, coma; then - psychomotor agitation, convulsions; rarely - hyperthermia and hyperemia of the skin. Treatment: gastric lavage, use of activated carbon (during detoxification in the early stages of an overdose as a result of oral administration of the drug); according to indications - anticonvulsants, mechanical ventilation and other resuscitation measures.

Interaction

Simultaneous use with MAO inhibitors helps to prolong and enhance the anticholinergic effects of Suprastin.

With caution, the medicine is prescribed with: tranquilizers , sedatives (including sedative analgesics ), muscarinergic parasympatholytics , atropine , tricyclic antidepressants . This is due to the fact that in combination with Suprastin these drugs exhibit synergistic action.

Alcohol potentiates the inhibitory effect of chloropyramine on the central nervous system, and therefore, during treatment with Suprastin, drinking alcohol should be avoided.

special instructions

The annotation states that the drug should be used with caution in elderly people, as well as in patients with heart pathologies and liver failure .

If taken in the evening, the drug may increase the symptoms of gastroesophageal reflux .

It should be remembered that chloropyramine can cause depression and drowsiness, interfering with certain types of activity. They are especially pronounced at the initial stages of treatment.

The doctor determines the degree of restriction on working with machinery and driving vehicles individually for each patient.

Application in veterinary medicine

Chlorpyramin can be used for drug therapy of allergic conditions in animals.

It is given orally 2-3 times a day. at a dose of 0.3-0.5 mg/kg. When administered intramuscularly, the dose for a horse is 5-6 ml, for a pig weighing 70-100 kg - 1-2 ml, for dogs the dosage depending on weight is from 0.1 to 0.5 ml. Injections are given 2 times a day.

Special instructions for the use of the drug Suprastin

In case of liver or heart diseases, prostate enlargement, open-angle glaucoma, difficulty urinating, the question of the appropriateness of using the drug Suprastin is decided individually, taking into account the benefit/risk ratio for each patient. During treatment, alcohol consumption is prohibited. During the entire treatment period, exposure to open sun should be avoided. After taking Suprastin, drowsiness may occur, so it is not recommended to drive during treatment. Particular caution is required when prescribing Suprastin to elderly patients.

Suprastin's analogs

Level 4 ATC code matches:
Chloropyramine

Pharmaceutical equivalents of the drug are Chlorpyramin , Chlorpyramin-Ferein , Chlorpyramin-Eskom .

The price of analogues in tablets is 85-90 rubles. 10 ampoules of the solution will cost approximately the same amount.

Drugs similar in mechanism of action: Alepriv , Histafen , Diazolin , Kestin , Ketotifen , Clarotadine , Lomilan , Loratadine , Peritol , Rapido , Suprastinex , Telfast , Erius .

Which is better - Suprastin or Tavegil?

Tavegil , the active ingredient of which is clemastine , is a highly effective drug, similar in its action to diphenhydramine ( Diphenhydramine , Allergin , Benadryl ). Characterized by high anticholinergic activity.

Both products are 1st generation drugs. The duration of the effect produced and the intensity of action are comparable.

Which is better - Cetrin or Suprastin?

Cetrin ( cetirizine hydrochloride ) is a 2nd generation drug that is a highly selective H1-type histamine receptor antagonist.

The drug has 2 release forms - tablets, which are used in patients over 6 years of age, and syrup, which is prescribed from 2 years of age.

Cetirizine hydrochloride is practically not biotransformed in the body; the rate of its elimination is related to the functional state of the kidneys. A special feature of the drug is its ability to penetrate the skin well, which makes Cetrin especially effective for skin manifestations of allergies .

The medicine does not have a proarrhythmic effect , which has been proven in preclinical and clinical studies.

This means that the use of Cetrin is much less likely to be accompanied by the development of adverse reactions than the use of 1st generation products. Moreover, the degree of expression of the latter is also less than that of Suprastin.

If we talk about antiallergic activity , then Suprastin is considered a somewhat stronger remedy.

Which is better: Zyrtec or Suprastin?

Zyrtec is a generic version of Cetrin , since both of these drugs contain the same substance - cetirizine . Thus, Zirtec has the same advantages over Suprastin as Cetrin .

Which is better - Suprastin or Diazolin?

The active substance of Diazolin is a blocker of histamine receptors of subtype 1, mebhydrolin , like chloropyramine , belongs to the 1st generation drugs. In comparison with its analogue, the product is characterized by less antiallergic activity. The sedative effect is slightly pronounced.

Suprastin or Zodak - which is better?

Zodak is a 2nd generation antiallergic drug with prolonged action. Its basis is cetirizine dihydrochloride , a substance characterized by the ability to selectively block peripheral histamine .

Does not have a pronounced anticholinergic and antiserotonin effect . sedation (including drowsiness) when used in therapeutic doses.

Which is better: Loratadine or Suprastin?

Loratadine is a 2nd generation antihistamine, which is characterized by high binding strength to peripheral histamine . It has no sedative effect , does not have cardiotoxic effects and does not enhance the effects of alcohol.

Loratadine practically does not interact with other medications.

Which is better: Suprastin or Claritin?

Since the active ingredient of the drug Claritin is loratadine , the choice between it and Suprastin should be made taking into account the features described above.

Analogues and important information

Among the analogues in pharmacies there are a variety of antihistamines, which are sold in the form of tablets or drops:

If the dose is exceeded, symptoms of overdose are observed. These include ataxia, anxiety, hallucinations, and seizures. In children, overexcitement, fever, dilated pupils and arrhythmia most often occur. In childhood, an overdose can cause death. It occurs against the background of coma, disruption of the heart and lungs. It is prohibited to take sedatives and tranquilizers during treatment with Suprastin - there is a danger of depression of consciousness due to a similar effect.

Alcohol and Suprastin

The drug is incompatible with alcohol.

What is Suprastin? This is antiallergic drug . Like other drugs from this group, it has a pronounced anticholinergic , hypnotic and sedative effect , which is enhanced in combination with alcohol.

Suprastin and alcohol: consequences of simultaneous use

Drinking alcohol during treatment with Suprastin can provoke symptoms such as:

• dizziness;
• blurred vision;
• a state close to panic;
• nervous excitability;
• dry mouth;
• euphoria;
• unstable stool;
• nausea;
• convulsions;
• vomit;
• tremor;
• tachycardia;
• ocular hypertension;
• a sharp drop in blood pressure;
• arrhythmia;
• urinary retention;
• lethargy;
• drowsiness.

What kind of drug is Suprastin?

Suprastin is an antihistamine from the group of H-histamine receptor blockers. It is available in two forms - injection solution and tablets. Usually in childhood Suprastin is prescribed in tablets, and injections are used in acute cases of allergies.

The active substance of the drug is chloropyramine hydrochloride (chloropyramine). Other Ingredients:

• talc;
• starch;
• lactose monohydrate, etc.

In ampoules, the drug, in addition to the active component, contains injection water. The tablets contain 25 mg of chloropyramine, appear white or grayish, and are engraved according to the name. Tablets have a risk for division.

The price for a package of 20 tablets is 130 rubles, the price of 5 ampoules of 1 ml is 160 rubles.

Chloropyramine is created from tripelenamine by chlorination. Its main effect is antihistamine; as a side effect, the drug has hypnotic, antiemetic, antispasmodic and sedative effects. After administration, the medicine blocks specific H1-histamine receptors. This allows you to prevent allergic reactions, as well as stop the existing release of histamine. Chlorapyramine also reduces capillary permeability, which helps eliminate swelling.

Suprastin during pregnancy and breastfeeding

Can pregnant women take Suprastin?

There are no data from preclinical studies on the use of the drug during pregnancy.

Adequate studies with proper control of the use of the drug in pregnant women have also not been conducted. However, there is evidence that in newborn infants whose mothers took antihistamines , connective tissue developed behind the lens of the eye.

In the description of the drug, the manufacturer warns that the use of Suprastin - especially in the 1st trimester and in the last weeks of the 3rd trimester - is possible only after a careful assessment of the beneficial effects and possible risks.

As for use in the 2nd trimester, the drug is also prescribed during this period after the risks to the fetus and the benefits to the mother’s body have been analyzed.

Thus, the question of whether Suprastin can be taken during pregnancy can only be answered by a doctor monitoring a pregnant woman.

Suprastin during lactation: can nursing mothers take antihistamines?

In the absence of well-controlled, adequate data on the use of the drug in breastfeeding, it is not recommended for use in breastfeeding women.

How long does it take for Suprastin to work?

The antihistamine drug Suprastin for allergies has been successfully used for a long period of time to relieve any conditions that are associated with the uncontrolled process of histamine release. In emergency cases, injectable forms for intramuscular and intravenous administration are used to quickly eliminate negative symptoms. For long-term treatment of chronic diseases, it is recommended to use Suprastin tablets in dosages recommended by the attending physician, taking into account the age and condition of the patient.

Can be used in complex therapy of allergic diseases in both children and adults.

Suprastin is contraindicated during pregnancy. However, sometimes exceptions are made, this is due to its versatility, speed and low price. The 1st trimester in this regard is the most important due to the beginning of the formation of all vital organs.

The negative impact of the drug during this period is considered maximum. According to some studies, when a pregnant woman takes Suprastin, a miscarriage or developmental defects in the baby are possible. Therefore, the drug is not prescribed.

Reviews about Suprastin

Reviews of Suprastin for children and adults prove the high antihistamine activity of this drug. The product is effective for the treatment of allergic rhinoconjunctivitis (both year-round and seasonal), urticaria , Quincke's edema , eczema , atopic dermatitis , itching of various etiologies.

In parenteral form, the drug has proven itself well in conditions that require emergency care.

The advantages of the drug are proven effectiveness, a wide range of therapeutic doses used, speed of action, short duration of side effects, controllability of the clinical effect, low cost. The active substance of the drug does not accumulate in the serum, which eliminates the possibility of overdose with long-term use.

Wikipedia indicates that Suprastin is included in the Russian list of vital and essential drugs.

Main indications in children

It is recommended to give the medicine to children at the initial signs of an allergic reaction or with a developed picture of the allergy. The therapeutic effect of Suprastin develops after 15 minutes, the maximum effect is observed after an hour.

The medicine is excellent for food allergies, which can occur in response to consumption of the following foods:

• nuts;
• fish;
• honey;

• chocolate;
• berries, fruits;
• eggs, etc.

In addition to food allergic reactions, the drug can be taken for a pathological reaction to insect bites - bees, midges, wasps and others. Suprastin is given to a child against allergic rhinitis, hay fever, and conjunctivitis.

Among skin reactions, the drug is excellent for contact and atopic dermatitis, neurodermatitis.

The drug is recommended for chickenpox - it will help eliminate skin itching; you can also take the medicine for itching of unknown origin (as a symptomatic remedy). Suprastin is prescribed to children during infectious diseases - together with Analgin and Paracetamol, it reduces the temperature faster. The drug, together with No-shpa, is used when the temperature is difficult to reduce - to relax the vascular walls. Other indications in children:

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• hives;
• Quincke's edema;
• acute, chronic eczema;
• allergies to medications;

• prevention of exacerbations of bronchial asthma;
• obstructive bronchitis;
• cough with pharyngitis of an allergic nature;
• sun allergy;
• cold allergy;
• serum sickness.

The medicine is prescribed along with antibiotics to reduce the risk of allergies to these drugs. Suprastin is given before vaccination to reduce the risk of allergic reactions.

How much do Suprastin tablets and injections cost?

The price of Suprastin tablets in Russia is from 110 rubles. The price of Suprastin in ampoules is from 150 rubles.

The average price in Ukraine for tablets 25 mg No. 20 is 65 UAH, the price of Suprastin 25 mg No. 10 is from 29 UAH. The d/i ​​solution can be purchased in pharmacies in Kharkov and Kyiv for 67-85 UAH. At the same time, the cost of 1 ampoule is 14-16 UAH.

For patients who are more comfortable using drops, Egis has developed the drug Suprastinex based on levocetirizine. Its cost is from 1060 rubles. in Russian, and from 350 UAH in Ukrainian pharmacies.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Suprastin tab.
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• Suprastin 20 mg/1 ml No. 5 solution ZAT FZ Egis, Ugorshchina
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• Suprastin tablets Suprastin tablets. 25 mg No. 20 Hungary, Egis

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