Cycloferon: how to take and contraindications

Composition and dosage forms

The active substance of the drug is meglumine acridone acetate - acridone acetic acid. It is a stimulator of interferon production, which has an antimicrobial, anti-inflammatory effect and inhibits the development of tumors.

Cycloferon is produced in forms for oral, parenteral and local use:

Coated tablets: brown or yellow, biconvex. The composition includes: 150 mg of active substance, methylcellulose and calcium stearate as auxiliary compounds. Packages contain 10 and 50 pcs.
Injection. Transparent yellowish liquid in 2 ml ampoules. The content of meglumine acridone acetate is 250 mg per ampoule. Additional components: water and stabilizers.
Liniment for topical use: a thick, gel-like yellow substance containing 5% active substance. Available in 5 ml tubes.

Cycloferon price, where to buy

The average price of Cycloferon No. 10 tablets is 150 rubles.

The price of Cycloferon in ampoules is on average 300 rubles per pack of 5 ampoules. The price of Cycloferon injections in Ukraine (Kyiv, Kharkov and other cities) is from 150 to 160 hryvnia for 5 ampoules. You can buy ampoules at a lower price by ordering online. How much an injection solution or tablet costs should be found in a specific pharmacy chain.

The price of Cycloferon ointment is on average 270 rubles per 30 ml. Liniment can also be bought in Ukraine, its cost is from 100 to 120 hryvnia per 30 ml.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Cycloferon tablets p.p.o.
enteric solution 150 mg 20 pcs. LLC NTFF POLYSAN 398 rub. order
Cycloferon tablets p.p.o. enteric solution 150 mg 10 pcs. LLC NTFF POLYSAN
RUB 213 order
Cycloferon tablets p.p.o. enteric solution 150 mg 50 pcs. LLC NTFF POLYSAN
RUB 853 order

Pharmacy Dialogue

Cycloferon (tab. 150 mg No. 50) Polisan NTFF
934 rub. order
Cycloferon (amp. 12.5% 2ml No. 5) Polisan NTFF
RUB 323 order
Cycloferon (tab. 150 mg No. 20) Polisan NTFF
RUB 385 order
Cycloferon (tab. 150 mg No. 10) Polisan NTFF
RUB 207 order
Cycloferon (tab. 150 mg No. 50) Polisan NTFF
RUB 813 order

Pharmacy24

Cycloferon 2 ml N5 solution TOV NTFF Polisan, Russian Federation
239 UAH order
Cycloferon 150 mg No. 10 tablets TOV NTFF Polisan, Russian Federation
111 UAH order
Cycloferon 150 mg N50 tablets TOV NTFF Polisan, Russian Federation
452 UAH order

PaniPharmacy

Cycloferon tablets Cycloferon tablets. 150 mg No. 10 Russia, Polisan
120 UAH order
Cycloferon ampoule Cycloferon injection solution 12.5% 2ml ampoules No. 5 Russia, Polisan
299 UAH order
Cycloferon tablets Cycloferon tablets. 150 mg No. 50 Russia, Polisan
484 UAH order

Mechanism of action of Cycloferon

The drug corrects the body's immunity by activating the production of interferons. When administered orally, meglumine is concentrated in the tissues of the liver, spleen, lungs, and intestines, on which the production of lymphocytes depends. Cycloferon also accelerates the release of granulocytes in the bone marrow.

The medicine inhibits autoimmune processes, reducing the body's pathological reaction to rheumatoid arthritis and other systemic diseases, and reduces the body's negative reactions during chemotherapy. When applied topically, the ointment reduces inflammation and has an antiproliferative effect.

The highest concentration of Cycloferon in the body is observed 2.5–3 hours after administration. Over the next 4–5 hours, it decreases by half. Complete elimination of the drug takes 1–1.5 days. The active substance is not deposited in tissues, does not provoke mutation processes, and does not cause intoxication.

CYCLOFERON is a modern immunomodulatory agent

For adults, CYCLOFERON is prescribed intramuscularly or intravenously 1 time per day according to the basic regimen: on days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23, 26, 29. The course of treatment is 5–12 injections depending on the nature of the disease.

For acute viral hepatitis - a single dose of 0.25–0.5 g, course of treatment - 10 injections. For chronic hepatitis B, maintenance therapy is carried out according to the following regimen: 0.25 g 1 time every 5 days for up to 3 months. For hepatitis C and mixed forms - 0.5 g once a week, course of treatment - 6 months.

For herpes and cytomegalovirus infection, the course of basic treatment is 10 injections (2.5 g). Therapy is most effective at the beginning of an exacerbation. For frequently recurrent forms of herpetic infection, CYCLOFERON is combined with other antiherpetic drugs.

For neuroinfections (serous meningitis, tick-borne borreliosis, multiple sclerosis, etc.), the course of basic therapy is 12 injections (3–6 g), if necessary, repeated courses.

For bacterial and fungal infections, the course of basic therapy is 5 injections (1.25 g) with mandatory combination with etiotropic therapy. Repeat the course after 5–7 days as needed.

For chlamydial infection, the course of basic therapy is 10 injections (2.5–5 g). Repeating the course after 3-4 weeks is mandatory, as is combination with antibiotics. The most effective inclusion of the antibiotic is after the 2nd injection of CYCLOFERON. It is mandatory to change the antibiotic from the 11th day of treatment with CYCLOFERON. For mixed infection, intravenous administration of the drug is recommended.

For HIV infection (stages 2A–3B), a course of basic monotherapy with CYCLOFERON is 10 injections of 0.5 g (the first 3 injections intravenously, then intramuscularly), maintenance treatment is once every 7 days for up to 1 year.

For immunodeficiency conditions - 10-12 injections of 0.25 g, maintenance course - 0.25 g once every 5-7 days for 4-6 months.

For rheumatic and systemic connective tissue diseases - 4 courses of treatment, 5 injections (1.25 g) with a break of 10-14 days. For degenerative-dystrophic diseases of the joints - 2 courses of 5 injections (1.25 g) with a break of 10-14 days. Repeat the course of treatment as needed.

For children over 4 years old, CYCLOFERON is prescribed intramuscularly and/or intravenously once a day, the daily dose is 6–10 mg/kg.

For acute viral hepatitis A, B, C, delta, GP and mixed forms, the drug is administered on 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28- e day. The course is 3.75 g. In case of prolonged infection, the course is repeated after 10–14 days.

For chronic viral hepatitis B, C, delta, GP and HIV infection, the drug is administered on days 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 and then for maintenance treatment according to the regimen 1 time per 5 days for 3 months while maintaining the indicators of replicative and cytolytic activity of the pathological process. The course of treatment is 7 years. For chronic hepatitis C, mixed forms of hepatitis and HIV infection, the course of maintenance therapy can be extended to 6 months.

For herpetic infections (herpes simplex, cytomegalovirus infection, infectious mononucleosis, etc.), the drug is administered on days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23. The course of treatment is 2.5 g. If the replicative activity of the virus remains, maintenance treatment is continued according to the regimen - once every 5 days for up to 4 weeks. Combination with other antiherpetic drugs is recommended.

CYCLOFERON is compatible with other medications. No side effects have been identified with its use. CYCLOFERON is not recommended for use during pregnancy and breastfeeding, or for patients with decompensated cirrhosis of the liver.

CYCLOFERON is produced in the form of a 12.5% sterile aqueous solution in 2 ml ampoules or in the form of a lyophilized powder in vials or ampoules of 0.25 g of active substance.

For purchasing questions, please contact Medical Academy Pharmacies LLC by phone/fax: (0562) 37-24-92; 37-24-93

Indications

Cycloferon is used in patients from 4 years of age:

in the treatment of herpetic infections;
for neuroinfections;
cytomegalovirus;
intestinal inflammation of a viral nature;
for the treatment of acute respiratory viral infections, acute respiratory infections;
in the complex treatment of viral hepatitis, HIV.

Liniment is used in the treatment of urogenital infections. The solution is also indicated for chlamydia and connective tissue diseases.

Pharmacological properties of the drug Cycloferon

cycloferon (N-(1-deoxy-d-glucitol-1-yl)-N-methylammonium-10-methyl-carboxylate of acridone - a salt of acridoneacetic acid and N-methylglucamine, a water-soluble synthetic analogue of the natural alkaloid Citrus grandis. Cycloferon is a low-molecular-weight synthesis inducer interferon, the main producers of which are macrophages, T- and B-lymphocytes. Induces high titers of interferon in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates bone marrow stem cells, stimulating the formation of granulocytes. Cycloferon is effective as an immunomodulator for viral diseases, in complex therapy of acute and chronic bacterial infections. Corrects the immune status of the body in immunodeficiency states of various origins and autoimmune diseases. Highly effective in rheumatic and systemic connective tissue diseases, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects. After parenteral administration, it penetrates quickly into cells and induces the synthesis of early interferons. Maximum activity is achieved after 2–4 hours. About 99% of the administered cycloferon is eliminated unchanged by the kidneys within 24 hours. Penetrates the BBB, leading to the formation of interferons in brain tissue. Does not accumulate with prolonged use. Recently, limited clinical studies have established the high effectiveness of cycloferon for the prevention and treatment of influenza and other acute respiratory viral infections during the epidemic in children and adults, in the treatment of psoriasis, herpes zoster, endometriosis, and diffuse fibrocystic mastopathy. The indications have been expanded and schemes for the use of cycloferon in dermatovenerological practice have been developed - in the treatment of mycoplasmosis, gardnerellosis, syphilis, candidiasis and other mycoses, trichomoniasis, psoriasis, atopic dermatitis, etc. For the emergency prevention of influenza during an epidemic and the treatment of its mild and uncomplicated forms, the following was effective scheme: 5 injections of cycloferon in 1; 2; 4; 6; days 8 (days 1–2 — 10 mg/kg body weight, day 4 — 8 mg/kg, days 6–8 — 6 mg/kg IM 1 time per day); for the treatment of severe and complicated forms of influenza and other acute respiratory viral infections - 10 mg/kg for 2 days, then 6 mg/kg IM or IV in 4 days; 6; 8; 10; 13; 16; 19th and 22nd days of treatment. For post-influenza neuroinfections - 2 ml IV or IM in 1 dose; 2; 4; 6; 8; eleven; 14; 17; 20th and 23rd days of treatment. For secondary recurrent and latent early syphilis (disease duration more than 6 months), a single dose of 0.25 g is used every other day, 10 injections per course of treatment. In the presence of aggravating factors (chronic alcoholism, drug addiction, tuberculosis), a second course of treatment is possible after 1.5–2 months. For trichomoniasis (the duration of the disease is more than 1 year), 2 courses of treatment with cycloferon are carried out: the first course - 5 intramuscular injections of 2 ml of solution, the second course - 10 injections according to the usual regimen. When treating bacterial vaginosis, a course of cycloferon injections (2 ml IM, 8–10 injections) is carried out when the disease lasts more than 6 months. For acute diarrhea of bacterial etiology in children - at a dose of 6–10 mg/kg per 1 dose; 2; 4; 6; 8th days in combination with other types of therapy. For diarrhea of viral origin, therapy with cycloferon in combination with probiotics is advisable. For intestinal dysbiosis, bacterial carriage - at a dose of 6 mg/kg per 1 dose; 2; 4; 6; 8; 10; 13; 16; 19; Day 22 (10 injections) in combination with vitamin therapy, enzyme preparations and probiotics.

Cycloferon for genital herpes

In addition to systemic therapy, applications with Cycloferon liniment are used:

a thin layer of the product is applied to the affected areas daily for 5–7 days;
use the drug for intravaginal or transurethral instillation, injecting 5 ml daily for 2 weeks;
cotton swabs soaked in ointment are inserted into the vagina for 10–15 days.

Cycloferon ointment can be alternated with the use of other topical drugs.

Contraindications

It is necessary to refuse treatment with the drug:

with uncompensated cirrhosis;
severe liver failure;
individual intolerance to components;
development of an allergy to the drug.

The medicine is also prohibited for the treatment of children under 4 years of age.

Those suffering from diseases of the gastrointestinal tract need to monitor their well-being when using tablets. In case of disturbances in the functioning of the endocrine system, treatment requires special care and medical supervision.