Dipentavak for dogs: instructions for use of the domestic drug

Content

1. Varieties 2. General information about the drug 3. How to use the drug correctly 4. Contraindications, possible negative consequences 5. Pros and cons 6. Existing analogues 7. Reviews

Pet owners should know: Dipentavak does not have any healing properties. The vaccine is administered solely for preventive purposes.

The formation of protective functions in the dog’s body occurs within 3 weeks. All this time the animal experiences increased stress. The effective period of protection against deadly infections lasts exactly 1 year. To maintain protective functions, annual revaccination is necessary. The dry component has a volume of 1.5 mm³, the volume of the suspension is 2.2 ml. The dry part of the preparation contains a live attenuated plague virus recorded in carnivores.

Corresponds to the Robcorn strain.

The second component is the rabies virus inactivated by ultraviolet rays (strain “Vnukovo-32”). The use of a stabilizer consisting of a mixture of gelatin and sucrose is provided as excipients.

The Dipentavak vaccination product consists of two main components that have a healing effect on the dog’s body:

Dipentavak

Vaccine against rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis in dogs. The Dipentavak vaccine consists of two components: dry - Divac and liquid - Pentavac. The dry component “Divac” is made from live attenuated canine distemper virus strain “Rockborn” and UV-inactivated rabies virus strain “Vnukovo-32”, lyophilized in a sucrose-gelatose medium. The liquid component of the Pentavac vaccine includes formaldehyde-inactivated canine parvovirus strain “D-I”, canine adenovirus of the second serotype strain “LT” and two Leptospira strains: “VGNKI-2” and “VGNKI-3” of the serological groups Icterohaemorrhagiae and Canicola. Aluminum hydroxide gel was added as an adjuvant. In appearance, the dry component of the vaccine is a dry amorphous mass of yellowish-pink color, the liquid component is a homogeneous pink suspension, during storage of which a loose light gray sediment is formed, which easily breaks when shaken. The dry component of the Divac vaccine is packaged 1.5 cm3 in sterile vials (ampoules) of appropriate capacity. Vials (ampoules) with a lyophilized drug are filled with inert gas, the ampoules are sealed, and the vials are sealed with rubber stoppers and rolled with metal caps. The liquid component of the Pentavac vaccine is packaged 2.2 cm3 in sterile vials (ampoules) of appropriate capacity. The ampoules are hermetically sealed, and the bottles are sealed with rubber stoppers and rolled with aluminum caps.

One bottle (ampoule) of Divac and Pentavac contains one vaccination (commercial) dose of the vaccine. Vials (ampoules) are marked with the indication of the manufacturer and (or) its trademark, the name of the vaccine component, designation of specifications, batch and control numbers, number of doses, storage conditions, expiration date, and the inscription “For animals.” Vials (ampoules) with the vaccine are packaged in 1, 5, 10, 100 doses in cardboard boxes or other containers that ensure their integrity. The packaging must have a label indicating the manufacturer and (or) its trademark, name of the drug, batch and control number, expiration date, number of vials (ampoules) and number of doses in the box, storage conditions, designation of specifications, method of application and the inscription “For animals”. Instructions for using the vaccine are included in each package. Vials (ampoules) without labels, with a violation of the integrity or tightness of the closure, with a changed color or consistency, containing foreign impurities, with an expired expiration date, frozen, and also if the vaccine is not used within 30 minutes after opening, are subject to rejection and disinfection by boil for 30 minutes followed by disposal. Pharmacological properties: The Dipentavak vaccine induces immunity in vaccinated animals against the pathogens of rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis of dogs 21 days after double application of the vaccine in puppies and a single application in adult dogs, which persists for 12 months. The vaccine is harmless, areactogenic and has no therapeutic effect.

Doses and method of administration: The Dipentavak vaccine is intended for the prevention of rabies, distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis in dogs. Only clinically healthy animals are subject to vaccination. Dogs are vaccinated starting from 60 days of age, twice with an interval of 2-3 weeks. Subsequent revaccination is carried out once after changing teeth. In the future, dogs are revaccinated once a year. The vaccine is administered subcutaneously into the scapula area or intramuscularly. 10 days before vaccination, dogs are dewormed. The use of specific sera and immunoglobulins is stopped two weeks before vaccination. Before immunization, the dry component of the Divac vaccine is dissolved in the liquid Pentavac. To do this, add 1.2 cm3 of the liquid component to the bottle (ampoule) with the dry component using a sterile syringe when vaccinating dogs weighing up to 5 kg and 2.2 cm3 of the liquid component when vaccinating dogs weighing more than 5 kg, shake thoroughly until completely dissolved and formed homogeneous suspension. Syringes and needles are sterilized by boiling for 20 minutes. Sterilization of syringes and needles with chemicals is not permitted. The use of disposable syringes is recommended. In some cases, a small swelling may form at the injection site, disappearing within 3-5 days. Vaccinated animals are monitored for two weeks.

It is prohibited to vaccinate: - sick animals, - with elevated body temperature, - puppies under 60 days of age, - puppies during the period of teeth change, - pregnant females in the second half of pregnancy.

Storage conditions: The vaccine has a shelf life of 12 months from the date of manufacture if stored in a dry, dark place at a temperature of 2 to 8°C. After the expiration date, the vaccine is not suitable for use.

, Russia

Varieties

When the drug is administered, a sufficient number of microorganisms enter the body, providing stable immunity to aggressive viruses. All these microorganisms are non-living, so they cannot harm the pet’s health, there is no threat. But the instructions for use specifically stipulate the procedure and correctness of the preparation of the vaccine and its administration.

The user should be aware that both components of the vaccine are contained separately, packaged in different glass containers. The sealing of the packaging is ensured by rubber stoppers secured with aluminum lids. Such precautions are necessary. When the medicine is taken into the syringe, not only is it sealed, but it is also protected from the penetration of bacteria.

• Pentavac.
  A substance in the form of a liquid in which congaria of parvovirus enteritis, hepatitis and other dangerous pathogens are dissolved.

The domestic pharmaceutical market is steadily developing, and the quality of developed medicinal products for animals is becoming better. Gradually, our drugs not only become worthy analogues of foreign vaccines and medicines, but also surpass them.

One of these remedies is deservedly Dipentavak, a drug consisting of several components (in carefully selected proportions). With its help, specialists form lasting protection against various types of infectious diseases. The most dangerous manifestations of etiology are rabies and plague; they almost always lead to death.

General information about the drug

Your veterinarian will advise you on the need to use Dipentavac. Exclusively - based on the results of the examination, clinical tests, assessing the degree of risk of infection. All indications for use are described in detail in the instructions included with Dipentavak for dogs.

Dosage form

• Divac
  is a powdery substance containing plague strains, microorganisms that cause rabies.

Each glass container contains one dose for one-time administration of mixed powder and suspension. During packaging, the free space in the containers is filled with inert gas.

The vaccine can protect against major infections:

The standard release form is a set of two hermetically sealed glass ampoules. In one there is a dry powder, in the other there is a liquid substance, a suspension. It should be administered immediately after preparing the mixture as a single injection.

The composition of the drug includes the dry component (powder) “Divak”, which is a lifilizate necessary for the preparation of an injection solution. The second component of Pentavac is a liquid suspension. Both substances mixed immediately before injection constitute 1 dose.

In what cases is it recommended by a veterinarian:
The liquid component of the drug contains canine parvovirus (strains “D-1”, “LT”, “VGNKI-2” and “VGNKI-3”. All components are inactivated with formaldehyde, to which the adjuvant of aluminum hydroxide is added .

• Enteritis caused by parvovirus infection (especially aggressively affects the heart tissue and gastrointestinal tract of a four-legged pet);
• Canine distemper (caused by a zoonotic bacterium);
• The most dangerous pathologies of a respiratory nature (provoked by adenoviruses);
• Leptospirosis is a disease that causes damage to the liver, kidneys, capillaries, and muscle tissue, accompanied by general intoxication of the body.
• Rabies (scientific name - rabies), which severely affects the central nervous system (CNS);
• Hepatitis (causes devastating liver damage).

If left untreated, the disease can be fatal.

Composition and release form

The vaccine is produced in glass vials. One dose includes two components, each of which is packaged in a separate bottle:

The dry component or “Divac” is a dried mixture of light yellow color with a pinkish tint. Contains a weakened live canine distemper virus and a rabies pathogen killed by ultraviolet light. Sucrose and gelatin were added as stabilizing substances.

The liquid component or “Penktavak” is a pink solution containing strains of parvovirus, adenovirus, and leptospiros. Pathogens are inactivated using a formalin solution with a concentration of 0.3%. To enhance the effect, 10% aluminum hydroxide gel is added.

How to use the drug correctly

1. Immediately before use, both components should be mixed.
2. First, you need to draw Pentavac into the syringe through a puncture in the cap.
3. It is then injected into the Divac vial.
4. The resulting mixture should be shaken thoroughly to ensure complete dissolution.
5. Refill the syringe with the resulting solution.
6. Before introducing the vaccine into the animal's muscles, the needle is changed to a new one.

The place of administration of the drug is subcutaneously, intramuscularly, in the scapular area. An injection into the muscle part of the thigh is allowed.

When to use

The instructions for Dipentavak for dogs also indicate what infections this vaccine protects against, these are:

• plague caused by a zoonotic bacterium;
• rabies that severely affects the central nervous system (rabies);
• aggressive enteritis caused by parvovirus that has a detrimental effect on the gastrointestinal tract and heart tissue of an animal;
• dangerous respiratory pathologies provoked by adenoviruses;
• leptospirosis, accompanied by damage to the capillaries, liver, kidneys, muscles and general intoxication of the body;
• Infectious hepatitis, which has a detrimental effect on the liver.

These diseases are deadly for dogs if appropriate therapeutic measures are not taken. Puppies especially suffer in this regard, starting from 3 months of their life (very small ones are protected by mother’s milk) and young dogs up to a year old.

The vaccine in question provides excellent immunity to dogs from these infectious diseases. And if infection does occur, they tolerate it calmly, leaving hope for recovery.

Method of use

Before use, the rare and dry components of the drug are mixed. First, Pentavac is drawn through a puncture in the cap with a syringe, which is sent into the bottle with Divac in the same way. The resulting mixture is shaken well until the dry substance is completely dissolved and the syringe is filled with it again. When the vaccine needs to be administered, the needle is replaced.

There are no particular difficulties regarding where to inject Dipentavak into a dog. The product is injected under the skin in the scapular area or an intramuscular injection is used in the upper thigh.

If immunization is carried out initially, the manipulation will need to be repeated after three weeks. This order is maintained for animals of any age. Regarding revaccination, the injection is given once. For puppies it is done after the change of teeth, and then once a year, for other dogs – annually.

The dosage of the drug is directly related to weight. If it does not exceed 5 kg, then a one-time norm is introduced - 1.2 ml of Pentavak, more than 5 kg - 2.2 ml. Regarding the dry part, Girl, it is used regardless of the dog’s weight in full.

Rules you need to know about

Immunization of dogs with Dipentavak involves a certain order in the preparatory and post-vaccination period:

• Giving the animal an anthelmintic 10 days before vaccination - the presence of worms negatively affects the body's defenses and can contribute to the occurrence of complications;
• Refusal two weeks before immunization from treating the dog with special serums and immunoglobulins;
• Perform the manipulation of administering the vaccine only with disinfected instruments, preferably with disposable syringes. The vaccination site is not subject to treatment;
• Avoiding walks with a vaccinated dog in areas where there are many dogs or contact with them on the street for 21 days (until immunity is formed);
• Observation of the vaccinated dog for two weeks.

Moreover, failure to comply with these rules may reduce the effectiveness of Dipentavak vaccination.

Contraindications, possible negative consequences

The practice of using Dipentavak did not reveal any deviations in the vital functions of pets.
It is not recommended to use vaccination for young puppies under 3 months of age; be careful with a pregnant female. The vaccine should not be administered to sick, malnourished animals or individuals with weakened immune systems. It is important to maintain proportions and then there will be no negative consequences:

• for body weight up to 5 kg, 1/2 ml of the product is allowed;
• if the animal weighs more than 5 kg, the dose is increased to 2.2 ml.

Side effects are minor. They are expressed by the appearance of small swellings at the site of needle insertion; for a certain period of time, the animal may lose its appetite.

Contraindications and side effects

Recommendations for the drug indicate in which cases it is not permitted to vaccinate a dog with Dipentavak. As already noted, these are puppies of two months of age, and also when their teeth change.

Premature whelping, as well as various complications, can also be caused by the vaccine in bitches if the vaccine is given during the second trimester.

This vaccination is also contraindicated:

• sick, malnourished dogs;
• at elevated temperatures;
• if they have any infectious pathologies.

Only completely healthy animals are subject to vaccination.

If the components of Dipentovak can cause allergies (usually rare), then before giving the injection the dog must be given an antihistamine. The side effects of Dipentavac for dogs are not varied. There are only a few of them:

• possible swelling in the place where the injection was given;
• depression and apathy of the immunized animal;
• loss of appetite.

All these phenomena go away on their own after some time and do not require treatment.

Features of storage and use

The Dipentavak vaccine must be stored at 2-10°C. Sun rays are also not recommended for the drug. For this reason, it is often put in the refrigerator. However, you need to make sure that it is not near food.

From the date of manufacture, Dipentavak remains effective for a year. After the specified period it cannot be used. Do not use a drug that has:

• damage to the seal in the packaging;
• insoluble sediments at the bottom;
• flakes or foreign matter in suspension;
• gaps in required labeling or no label at all.

Vaccine that is not to be used is destroyed. However, it should first be boiled for five minutes - this will render it harmless. The same is done with Dipentavak, which was not used within half an hour after opening the bottle.

Price

The domestic vaccine Dipentavak is quite inexpensive - from 260 rubles. per dose. You can buy it freely at any veterinary pharmacy or online. In the latter case, it is important to contact trusted places, since its proper storage remains a very important issue.