The influence of staged prevention of intrauterine infection on the health of children born to mothers with recurrent herpetic infection
Authors: Ovchinnikova Marina Alekseevna
A combined method of managing patients with laryngeal panillomatosis in combination of surgical and conservative treatment
Authors: Volkova Karina Borisovna
The influence of qualitative characteristics of the endometrium on the effectiveness of IVF in women with tubo-peritoneal infertility
Authors: Vasyukhina Anna Aleksandrovna
Cervical cancer in Karelia: epidemiological, clinical, immunological and preventive aspects
Authors: Kovchur Pavel Ivanovich
Expression of early response genes and caspase genes as a possible diagnostic marker in the development of cervical cancer
Authors: Kurmyshkina Olga Vadimovna
Clinical and pathogenetic significance of tissue acidosis in patients with herpes simplex during different periods of the disease and optimization of anti-relapse measures
Authors: Ryazanova Olga Arturovna
Clinical and molecular genetic basis of precancer and early forms of cervical cancer
Authors: Korolenkova Lyubov Ivanovna
The use of allokin-alpha in the complex treatment of papillomavirus lesions of the cervix in women of reproductive age
Authors: Komissarova Olga Nikolaevna
Clinical, pathogenetic and prognostic significance of changes in the immune status and antioxidant system in patients with herpes and HIV infection
Authors: Azovtseva Olga Vladimirovna
Guide for doctors “Use of Allokin-alpha in the treatment of viral infections”
Authors: F.I. Ershov, V.A. Isakov, G.P. Becker, M.Yu. Serebryakov, T.V. Sologub, N.B. Serebryannaya, M.S. Tishchenko, S.I. Chernysh, 2008
Human papillomavirus
Features of conservative immunoantiviral therapy for patients with HPV-associated cervical intraepithelial neoplasia of I degree
Authors: O. E. Epifanova, O. P. Vinogradova, N. A. Andreeva
Efficiency of therapy for genital diseases with a combination of papillomavirus and herpesvirus infections
Authors: prof., doctor of medical sciences Rogovskaya S.I., Ph.D. Bebneva T.N., prof., doctor of medical sciences Polonskaya N.Yu. and etc.
New possibilities for the treatment of human papillomavirus infection
Authors: Perlamutrov Yu.N., Chernova N.I.
Experience of using Allokin-Alpha in the treatment of HPV-associated diseases
Authors: prof. Doctor of Medical Sciences Prilepskaya V.N., senior researcher Ph.D. Dovletkhanova E.R., Ph.D. Abakarova P.R., prof. Doctor of Medical Sciences Mezhevitinova E.A.
Reduction of viral load determined by the hybrid capture method (HC2 DNA HPV HR) in patients with severe intraepithelial neoplasia of the cervix as a result of effective pre-excision therapy with Allokin-Alpha
Authors: Doctor of Medical Sciences, Professor oncogynecologist Korolenkova L.I.
"Preconception preparation in patients with viral infections"
Authors: Sosnova E.A.
Clinical effectiveness of Allokin-Alfa and its effect on the expression of T-reg regulatory lymphocyte markers in the treatment of patients with chronic human papillomavirus infection
Authors: Kovchur P.I., Oleinik E.K., Bakhlaev I.E., Churov A.V., Oleinik V.M.
Reduction of the viral load of Hybrid Capture 2 as a result of effective pre-excision therapy with Allokin-alpha in patients with CIN 2-3/preinvasive cervical cancer
Authors: Korolenkova L.I., Bryuzgin V.V.
"Allokin-Alpha in complex therapy of human papillomavirus infection in women with cervical diseases"
Authors: Academician of the Russian Academy of Sciences F.I. Ershov, Doctor of Medical Sciences P.I.Kovchur, Ph.D. I.E. Bakhlaev
“The role of Allokin-alpha in the complex treatment of papillomavirus lesions of the cervix”
Authors: S.N. Gaidukov, O.N. Komissarova
"Alloferon preparations in the treatment of human papillomavirus infections"
Authors: M.D.Ivashchenko, M.Yu.Serebryakov, M.S.Tishchenko
Experience with the use of the drug Allokin-Alpha in the treatment of patients with recurrent laryngeal papillomatosis
Authors: F.D. Evchev, A.F. Evcheva
Persistent human papillomavirus infection: cytokine imbalance and approaches to therapy
Authors: I.N. Zuikova, A.E. Shulzhenko
The use of antiviral therapy in the complex treatment of patients with verrucous leukoplakia
Authors: O.F. Rabinovich, I.M. Rabinovich, A.A. Togonidze, A.A. Bezrukov, L.P. Agapitova TsNIISiChLKh, Moscow, 2021
Allokin-alpha did not help. Why?
From many years of practice it follows that in most cases, there is no effect of HPV elimination when treated with Allokin-alpha (except for 10% of patients who require immunocorrection before starting treatment) the reason is hidden in the random (not intentional) distortion of methods for prescribing and using the drug Allokin-alpha:- HPV can be treated with the drug Allokin-alpha at a dosage of 1 mg (at the moment the drug is produced only in this dosage)
- 6 injections per course of treatment
- Every other day (after 48 hours)
NB: Currently, it is theoretically justified to administer the drug Allokin-alpha after 72 hours, which, according to scientists, will significantly increase the effectiveness of the drug in the treatment of HPV, but this theory has not yet been confirmed by practical studies, so it is recommended to follow the instructions exclusively: “ The drug is administered subcutaneously. The standard course of treatment for infections caused by oncogenic types of human papillomavirus includes injections of the drug at a dose of 1 mg every other day, for a total of 6 injections per course. »
- SUBCUTANEOUSLY!!! (PC).
NB: The most common mistake leading to ineffective use of the drug is intramuscular administration (IM)! With this form of administration, the drug relieves the patient from pain, burning and itching within 10-15 minutes when treating genital herpes, but does not have a systemic effect on HPV. The drug is administered intramuscularly by medical workers (or the patients themselves) not intentionally; in most cases, attempts to inject the drug into the usual place for subcutaneous injections - into the lateral (side) surface of the forearm in slender women - simply end up. The nurse tries to inject the drug subcutaneously into the lateral surface of the forearm, but often injects it intramuscularly, because The insulin needle easily and easily penetrates the skin, poorly defined subcutaneous tissue and enters the muscle. To avoid a technical error and guarantee the injection of the drug subcutaneously into a slender woman, most doctors who perform subcutaneous injections on their own use the following technique: “With the thumb and index finger of the left hand (pinch), the skin on the front surface of the patient’s thigh is pulled and into the resulting void (between the skin pinched with the pinch and the thigh muscle not affected by the pinch) the needle of an insulin syringe is safely inserted through the skin.” Such missteps also happen for other reasons: the doctor prescribes the drug subcutaneously, and the manipulative nurse in the hustle and bustle administers the drug intramuscularly... or the patient administers the drug herself (in an attempt to save time on a trip to a medical facility for the next injection) without having the proper skills for subcutaneous administration...
Cervical dysplasia
Features of conservative immunoantiviral therapy for patients with HPV-associated cervical intraepithelial neoplasia of I degree
Authors: O. E. Epifanova, O. P. Vinogradova, N. A. Andreeva
The fight against HPV: many facets of a single task. Complex therapy of HPV-associated diseases
Authors: Academician of the Russian Academy of Sciences, Doctor of Medical Sciences prof. Radzinsky V.E., prof. Ordiyants I.M., Ph.D. Bebneva T.N.
Reduction of viral load determined by the hybrid capture method (HC2 DNA HPV HR) in patients with severe intraepithelial neoplasia of the cervix as a result of effective pre-excision therapy with Allokin-Alpha
Authors: Doctor of Medical Sciences, Professor oncogynecologist Korolenkova L.I.
Clinical effectiveness of Allokin-Alfa and its effect on the expression of T-reg regulatory lymphocyte markers in the treatment of patients with chronic human papillomavirus infection
Authors: Kovchur P.I., Oleinik E.K., Bakhlaev I.E., Churov A.V., Oleinik V.M.
“The role of Allokin-alpha in the complex treatment of papillomavirus lesions of the cervix”
Authors: S.N. Gaidukov, O.N. Komissarova
Cervical intraepithelial neoplasia (diagnosis, treatment, prevention). Tutorial.
Authors: Academician of the Russian Academy of Sciences, Professor V.I. Krasnopolsky, Doctor of Medical Sciences, Professor L.S. Logutova, Doctor of Medical Sciences N.V. Zarochentseva, Ph.D. OK. Jijihia
Allokin-Alpha ampoules 1MG No. 3
Indications
Chronic human papillomavirus infection, chronic recurrent herpes types 1 and 2, as part of complex therapy for the moderate (icteric) form of acute hepatitis B.
Directions for use and doses
Allokin-alpha is administered subcutaneously. The standard course of treatment for infections caused by oncogenic types of human papillomavirus includes injections of the drug at a dose of 1 mg every other day, for a total of 6 injections per course. The standard course of treatment for recurrent herpes includes injections of the drug at a dose of 1 mg every other day, for a total of 3 injections per course. For moderate forms of acute hepatitis B, the drug is administered after verification of the diagnosis at a dose of 1 mg 3 times a week for 3 weeks (9 injections in total). To prepare a solution for injection, 1 ml of 0.9% sodium chloride solution is used as a solvent.
Compound
1 ampoule contains Alloferon 1 mg.
Contraindications
Hypersensitivity to the components of the drug; pregnancy and lactation; severe autoimmune diseases; children up to 12 years of age.
Side effects
Possible: weakness, dizziness, formation of new elements of herpetic rash.
Storage conditions
In a dry place, protected from light, at a temperature of 2 - 8°C.
Best before date
2 years.
pharmachologic effect
Allokin-alpha is an antiviral agent - an oligopeptide; its pharmacological action is close to interferon alpha. Inducer of the synthesis of endogenous interferons and activator of the killer cell system. Stimulates the recognition and lysis of defective cells by cytotoxic lymphocytes. Effective against infections caused by herpes simplex viruses type I and II, as well as hepatitis B and influenza viruses A and B. It does not have general toxicity, allergenic, mutagenic, carcinogenic, embryotoxic effects and does not affect reproductive function. An increase in interferon concentration is observed 2 hours after administration of the drug; a high concentration remains (2-2.5 times higher than the usual background) for 6-8 hours with a decrease to initial values by the end of the day. Increased functional activity of NK killer cells is observed within 7 days after drug administration.
Drug interactions
In the treatment of chronic recurrent genital herpes, it can be prescribed in combination with acyclovir. In acute hepatitis B, the drug is prescribed against the background of generally accepted basic therapy.
Genital herpes
Efficiency of therapy for genital diseases with a combination of papillomavirus and herpesvirus infections
Authors: prof., doctor of medical sciences Rogovskaya S.I., Ph.D. Bebneva T.N., prof., doctor of medical sciences Polonskaya N.Yu. and etc.
"Preconception preparation in patients with viral infections"
Authors: Sosnova E.A.
“Clinical effectiveness and mechanism of action of Allokin-alpha in patients with recurrent genital herpes”
Authors: F.I. Ershov, A.A Kubanova, A.E. Shulzhenko, B.V. Pinegin, G.P. Becker, S.I. Chernysh, L.V. Bugaev
"Use of Allokin-alpha in the treatment of herpes simplex and herpes zoster"
Authors: V.A.Isakov, V.N.Koryagin, G.P.Becker, M.Yu.Serebryakov.
"New approaches to the treatment of herpes virus infection"
Authors: Serebryannaya N.B. , Egorova V.N.
"The influence of Allokin-Alpha therapy on the course of relapses of chronic genital herpes"
Authors: F.I. Ershov, A.A. Kubanova, B.V. Pinegin, A.E. Shulzhenko, G.P. Becker, S.I. Chernysh, L.V. Bugaev
"Treatment of patients with herpes infection"
Authors: M.S. Tishchenko, M.Yu. Serebryakov, A.V. Vronov, D.Yu. Serebryakov
"Allokin-alpha in complex therapy of recurrent herpes infection"
Authors: V.A. Isakov, E.I. Arkhipova, O.V. Azovtseva, S.I. Chernysh, F.R. Kutueva, A.E. Semenov
References
- Lifshits, V.M., Sidelnikova, V.I. Medical laboratory tests. - M.: Triad X, 2007. - 312 p.
- Nesterova, I.V. Congenital and acquired interferonopathies: differentiated approaches to interferon-corrective therapy, Federal State Autonomous Educational Institution of Higher Education "Russian Peoples' Friendship University" of the Ministry of Education and Science of the Russian Federation, Moscow, 2021. - V. 16(2). — P. 50-53.
- Savenkova, M.S., Karashtina, O.V., Shabat, M.B. and others. Interferon status and choice of interferon inducers in frequently ill children. - Children's infections, 2021. - No. 2. - P. 45-51.
Urology
Experience with the use of Allokin-Alpha in the treatment of infectious and inflammatory diseases of the genitourinary system, complicated by an excretory-toxic form of infertility
Authors: O. V. Akimov, S. A. Kostromeev, A. A. Dyshkovets
Possibilities for improving the treatment of urogenital bacterial and viral infections
Authors: Perlamutrov Yu.N. Doctor of Medical Sciences, Professor, Chernova N.I. Doctor of Medical Sciences, Associate Professor
Modern methods of diagnosis and treatment of urogenital tract infections. A manual for doctors.
Authors: Honored Doctor of the Russian Federation Yu.N. Perlamutrov, Doctor of Medical Sciences, Associate Professor N.I. Chernova, Doctor of Medical Sciences, Professor I.M. Karimova
Forum about condylomas / Treatment of HPV with Allokin-alpha
Good evening everyone!!! I’ll tell you my story about HPV and Allokin-alpha. I’ll start from the beginning. in December 2009, after a course of treatment for ureaplasma, condylomas (13 pieces, small, judging by what they write here) appeared on the labia (there seemed to be nothing inside). Since at that moment it was not possible to see a doctor, I got an appointment only after the New Year holidays. They prescribed 6 injections of allokin-alpha every other day + epigen spray or panavir gel (I didn’t want to remove it surgically: it’s expensive, painful, and usually not effective). I pierced it and used epigen. So 2 weeks passed, the epigenes decreased slightly, but did not disappear. I tried Panavir, and 3 more appeared! Panic set in, I searched the entire Internet until I came across this forum! In my opinion, the only more or less positive one on this topic. I decided to try out all the remedies listed here. I started with iodine (I tried it on several) - there was no effect... I bought propolis tincture (on the advice of the author of one of the topics). I did everything as described, I didn’t even wash for 5 days)) I almost went crazy))) They became smaller again, but didn’t disappear... I went and bought a super cleanser, read about it on the Internet and decided to leave it as a last resort... I didn’t do anything for two weeks ..waited for the beginning of the waning moon.. Maybe this is all nonsense, of course, but in the end it helped!!! Just at this time I had a vacation and went with a friend to Egypt for a week, with full confidence that after the vacation everything would pass and I will be absolutely healthy. I bought Condilin. After one course they completely disappeared! Of course, it was very painful and uncomfortable for 4-6 days, because ulcers form and with every unsuccessful movement they are torn off, but everything went away, no traces remained!! today (April 13, 2010) I received tests!!! No traces of the virus!!! So, dear readers, to summarize, I’ll say: 1) don’t despair!!! You need to think positively, and the body itself will help get rid of this crap; and don’t blame your ex-partners, it still doesn’t help); 2) don’t be treated with any unnecessary crap that doctors prescribe for the sake of personal gain (from my experience: at *OnClinic* they tore me 3,000 rubles for a treatment regimen... heartbroken, I was confused and paid. Further treatment took place at the LitFond Polyclinic. Moscow at the paid department - excellent specialists, reasonable prices! But if you don’t trust it at all, you can get tested at Invitro); 3) do not remove external condylomas surgically, and before the course of Allokin (I read somewhere that if there is a virus, then after menstruation and it gets bigger, and then delete it, don’t delete it, nothing will change... First you need to destroy the virus itself); 4) and perhaps a healthy lifestyle during treatment won’t hurt either!!! (at least I gave up alcohol almost completely) I hope my post will help someone, as yours once helped me!!! I wish you a complete recovery!!!!
